Tachykinins in the pineal gland: effect of castration and ganglionectomy
| Autor: | Luciano Debeljuk, Agustín Arce, M G García Bonacho, Ana I. Esquifino, Andrzej Bartke |
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| Rok vydání: | 1998 |
| Předmět: |
Testosterone propionate
Male endocrine system medicine.medical_specialty Physiology medicine.medical_treatment Neurokinin A Biology Substance P Biochemistry Pineal Gland Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Pineal gland Endocrinology Internal medicine medicine Animals Circadian rhythm Ganglionectomy Castration Rats Wistar Testosterone respiratory system Immunohistochemistry Circadian Rhythm Rats medicine.anatomical_structure chemistry Darkness Cervical ganglia hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 19(6) |
| ISSN: | 0196-9781 |
| Popis: | In this investigation, the presence of NKA-immunoreactive substances was determined in pineal glands from intact, castrated and castrated, testosterone-treated male rats. The effect of environmental light, melatonin treatment and superior cervical ganglionectomy on pineal NKA-immunoreactive substances was also investigated. The results obtained show that NKA is present in measurable amounts in the rat pineal, and NPK is probably also present, Orchidectomy was followed by an increase in the content of NKA-immunoreactive substances in the pineal gland. The replacement treatment with testosterone propionate in castrated rats blocked this effect. NKA-immunoreactive substances were not significantly different quantitatively in pineals from rats killed under light or under darkness. The removal of the superior cervical ganglia was followed by a significant increase in the NKA-immunoreactive substance content in the pineal gland of male rats. These results indicate that NKA and other tachykinins are present in the pineal gland of the male rat, and they seem to be regulated by gonadal hormones and the innervation originated from the superior cervical ganglia. |
| Databáze: | OpenAIRE |
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