Diagnosis of dementias by high-field 1H MRS of cerebrospinal fluid
| Autor: | Mikko P. Laakso, Jouko Vepsäläinen, Niko Jukarainen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
In vivo magnetic resonance spectroscopy
Lewy Body Disease Male medicine.medical_specialty Pathology Parkinson's disease Proton Magnetic Resonance Spectroscopy Disease Neuropsychological Tests Gastroenterology Cerebrospinal fluid Sex Factors Alzheimer Disease Internal medicine mental disorders medicine Dementia Humans Stage (cooking) Vascular dementia Aged Aged 80 and over Memory Disorders Dementia Vascular Age Factors Reproducibility of Results Middle Aged medicine.disease Psychiatry and Mental health Frontotemporal Dementia Surgery Female Neurology (clinical) Psychology Cognition Disorders Frontotemporal dementia Follow-Up Studies |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry. 86(12) |
| ISSN: | 1468-330X |
| Popis: | Objective To test whether the information obtained from cerebrospinal fluid (CSF) and analysed with high-field proton ( 1 H) MR spectroscopy (MRS) would help the diagnosis of most common forms of dementia. Setting A total of 31 metabolites from CSF from 222 controls and patients suffering from various dementias (Alzheimer’s disease (AD), vascular dementia, Lewy body disease (LBD) and frontotemporal dementia (FTD)) were quantified using 1 H MRS. Main outcome measure Clinical diagnosis. Results AD was classified with an accuracy of 85.5%. For a group of very early stage patients with AD, the result was significantly higher, 92.3%. Vascular dementia, LBD and FTD were all diagnosed with 100% accuracy in controls and from AD with an accuracy ranging between 85.5% and 93.4%. Conclusions The results indicate that the composition of CSF contains enough information of the neurological state of a given patient with a given dementia to be diagnosed with extremely high accuracy. This approach might provide potentially a very powerful diagnostic tool to help the diagnostic process of dementias. |
| Databáze: | OpenAIRE |
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