Lactational exposure to dioxin-like polychlorinated biphenyl 169 and nondioxin-like polychlorinated biphenyl 155: Effects on rat femur growth, biomechanics and mineral composition
Autor: | Gregor Fazarinc, Katarina Pavšič Vrtač, Ines Anders, Milka Vrecl, Jana Brankovič, David Antolinc, Maja Antanasova, Janja Jan, Breda Jakovac Strajn, Peter Jevnikar |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Offspring Health Toxicology and Mutagenesis 0211 other engineering and technologies 02 engineering and technology 010501 environmental sciences 01 natural sciences Mineralization (biology) Dietary Exposure chemistry.chemical_compound Internal medicine Lactation Blood plasma medicine Animals Femur Rats Wistar 0105 earth and related environmental sciences Biphenyl Minerals 021110 strategic defence & security studies Public Health Environmental and Occupational Health food and beverages Polychlorinated biphenyl General Medicine Polychlorinated Biphenyls Pollution medicine.anatomical_structure Endocrinology chemistry Maternal Exposure Toxicity Environmental Pollutants Female |
Zdroj: | Ecotoxicology and Environmental Safety. 180:106-113 |
ISSN: | 0147-6513 |
Popis: | Exposure to polychlorinated biphenyls (PCBs), which are persistent lipophilic environmental pollutants, has a variety of adverse effects on wildlife and human health, including bone mineralization, growth and mechanical strength. The present study evaluated the effects of lactational exposure to nondioxin-like PCB-155 and dioxin-like PCB-169, individually and in combination, on pubertal rat femur development and its biomechanics. After offspring delivery, Wistar rat mothers were divided into four groups, i.e., PCB-169, PCB-155, PCB-155+169 and control, and were administered PCBs intraperitoneally. Data on bone geometry, biomechanics and mineral composition were obtained by analysis of femurs from 42-day-old offspring by microCT scanning, three-point bending test and inductively coupled plasma mass spectrometry. Decreased somatic mass and femur size, i.e., mass, periosteal circumference and cross sectional area, were observed in the PCB-169 and PCB-155 groups. Additionally, lactational exposure to planar PCB-169 resulted in harder and more brittle bones containing higher amounts of minerals. Combined exposure to structurally and functionally different PCBs demonstrated only mild alterations in bone width and mineralization. To conclude, our results demonstrated that alterations, observed on postnatal day 42, were primarily induced by PCB-169, while toxicity from both of the individual congeners may have been reduced in the combined group. |
Databáze: | OpenAIRE |
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