Chitosan-Based Delivery Systems Loaded with Glibenclamide and Lipoic Acid: Formulation, Characterization, and Kinetic Release Studies
| Autor: | Lenuta Profire, Luminita-Georgeta Confederat, Cristina Tuchilus, Sandra Constantin, Iuliana Motrescu, Mihaela Iustina Condurache, Alexandra Bujor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Infrared spectroscopy
02 engineering and technology macromolecular substances 010402 general chemistry 01 natural sciences lcsh:Technology Chitosan Matrix (chemical analysis) Glibenclamide lcsh:Chemistry chemistry.chemical_compound drug delivery systems medicine General Materials Science Instrumentation lcsh:QH301-705.5 Fluid Flow and Transfer Processes chemistry.chemical_classification lcsh:T Process Chemistry and Technology General Engineering technology industry and agriculture Polymer 021001 nanoscience & nanotechnology lipoic acid lcsh:QC1-999 0104 chemical sciences Computer Science Applications Lipoic acid chemistry lcsh:Biology (General) lcsh:QD1-999 glibenclamide lcsh:TA1-2040 Particle size Swelling medicine.symptom chitosan 0210 nano-technology lcsh:Engineering (General). Civil engineering (General) lcsh:Physics medicine.drug Nuclear chemistry |
| Zdroj: | Applied Sciences, Vol 10, Iss 7532, p 7532 (2020) Applied Sciences Volume 10 Issue 21 |
| ISSN: | 2076-3417 |
| Popis: | Glibenclamide and lipoic acid are two drugs frequently recommended for the management of diabetes mellitus, and so, the development of a new formulation containing both substances has a great benefit in terms of efficiency and compliance, acting also as a multi-target drug system. Accordingly, the aim of this study was the formulation and physicochemicalcharacterization of new polymeric systems based on chitosan (CS) in whose matrix were encapsulated glibenclamide (Gly) and lipoic acid (LA). The polymeric systems were prepared as microparticles (CS&ndash Gly, CS&ndash LA, and CS&ndash Gly&ndash LA) through ionic gelation method, using pentasodium tripolyphosphate (TPP) as crosslinking agent. The polymeric systems obtained were characterized in terms of particle size and morphology, IR spectroscopy, entrapment efficiency and drug loading, swelling degree, and therelease of the active substances from the chitosan matrix. The polymeric systems obtained were stable systems the presence of glibenclamide and lipoic acid into the polymer matrix were proved by IR spectroscopy. The entrapment efficiency was 94.66% for Gly and 39.68% for LA. The developed polymeric systems proved a favorable swelling degree and drug release profile, the percentage of release being 88.68% for LA and 75.17% for Gly from CS&ndash LA systems. |
| Databáze: | OpenAIRE |
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