Trimester- and Assay-Specific Thyroid Reference Intervals for Pregnant Women in China
| Autor: | Xiangying Meng, Yuchao Zhang, Jing Li, Xia Zhang, Zhongxing Lv, Enwu Yuan, Jinfang Xing, Yuan Tian, Liting Jia, Shouhua Rong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
endocrine system endocrine system diseases Article Subject Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology Thyroid-stimulating hormone Free thyroxin Thyroid peroxidase medicine Gynecology Pregnancy lcsh:RC648-665 biology Endocrine and Autonomic Systems business.industry Thyroid Control subjects medicine.disease Reference intervals medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Thyroid function business Research Article |
| Zdroj: | International Journal of Endocrinology, Vol 2016 (2016) International Journal of Endocrinology |
| ISSN: | 1687-8337 |
| DOI: | 10.1155/2016/3754213 |
| Popis: | Objective. The guidelines of the American Thyroid Association (ATA) recommend an upper limit reference interval (RI) of thyroid stimulating hormone (TSH) of 2.5 mIU/L in the first trimester of pregnancy and 3.0 mIU/L in subsequent trimesters, but some reported ranges in China are significantly higher. Our study aimed to establish trimester- and assay-specific RIs for thyroid hormones in normal pregnant Chinese women. Methods. In this cross-sectional study, 2540 women with normal pregnancies (first trimester, n=398; second trimester, n=797; third trimester, n=1345) and 237 healthy nonpregnant control subjects were recruited. Serum TSH, free thyroxin (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) levels were determined by automated chemiluminescence with an Immulite 2000 system (Siemens, Erlangen, Germany). After outliers were excluded, the 2.5–97.5th percentiles were used to define the RIs. Results. The RIs of thyroid function in the first, second, and third trimesters of pregnancy and in nonpregnant controls were 0.07–3.96, 0.27–4.53, 0.48–5.40, and 0.69–5.78 mIU/L for TSH and 9.16–18.12, 8.67–16.21, 7.80–13.90, and 8.24–16.61 pmol/L for FT4, respectively. Conclusion. The trimester- and assay-specific RIs of thyroid function during pregnancy differed between trimesters, which suggests that it is advisable to detect and avoid misclassification of thyroid dysfunction during pregnancy for women in Henan, China. |
| Databáze: | OpenAIRE |
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