Genotoxicity of the phosphoramidate agent tabun (GA)
| Autor: | Barry W. Wilson, Marvin Goldman, Norman Cone, John D. Henderson, Thomas G. Kawakami, Jack C. Dacre, L. S. Rosenblatt |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Salmonella typhimurium
endocrine system Lymphoma DNA damage Stereochemistry Mutagen Sister chromatid exchange Toxicology medicine.disease_cause chemistry.chemical_compound Mice In vivo medicine Tumor Cells Cultured Animals Tabun Chemistry Mutagenicity Tests fungi food and beverages Phosphoramidate DNA Molecular biology In vitro Organophosphates Mice Inbred C57BL Liver Female Cholinesterase Inhibitors Sister Chromatid Exchange Genotoxicity Cell Division DNA Damage Mutagens |
| Zdroj: | Toxicology. 86(1-2) |
| ISSN: | 0300-483X |
| Popis: | Five mutagenicity tests were performed on Agent GA (Tabun, phosphoramidocyanidic acid, dimethyl-, ethyl ester) as part of a program to demilitarize chemical warfare agents. GA was mutagenic in Salmonella spp. assays with S-9 and it was a direct-acting mutagen to mouse lymphoma cells. GA did not promote unscheduled DNA synthesis in rat hepatocytes; it induced sister chromatid exchanges in mouse cells in vitro but in vivo. The conclusion that GA is a weakly acting mutagen is supported by the fact that it was mutagenic in only three of the five assays, and that increases in mutagenicity were often less than 2-fold the controls and occurred near toxic levels. |
| Databáze: | OpenAIRE |
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