Diagnosis of Schistosomiasis by Complement-Fixation

Autor:	John J. Shapilo, Preston M. Bauman, Elmer F. Chaffee
Rok vydání:	1954
Předmět:	Heterologous Ether Schistosomiasis Complement System Proteins Biology medicine.disease Complement fixation test Serology Salt solution chemistry.chemical_compound Infectious Diseases chemistry Antigen Virology Immunology medicine Humans Helminths Parasitology
Zdroj:	The American Journal of Tropical Medicine and Hygiene. 3:905-913
ISSN:	1476-1645 0002-9637
DOI:	10.4269/ajtmh.1954.3.905
Popis:	Summary An improved antigen for the complement-fixation test has been prepared by extracting desiccated adult schistosomes with anhydrous ether in the cold (-15 to -18°C.) prior to final extraction with buffered salt solution. Preliminary extraction with ether markedly reduced a tendency of the antigen to react with syphilitic serum without appreciably altering its capacity to fix complement specifically with serum from schistosome-infected individuals. Sera from persons infected with S. mansoni or S. japonicum could not be differentiated on the basis of their capacity to react with antigens from the homologous and heterologous parasites. The complement-fixation test is discussed from the point of view of its value in the diagnosis of schistosomiasis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa5520a55bc5a33cf1902364ab23c73 https://doi.org/10.4269/ajtmh.1954.3.905 Zobrazit plný text záznamu