Programmed Death-Ligand 1 Expression and EGFR Mutations in Multifocal Lung Cancer
| Autor: | Yuka Kozuma, Kazuki Takada, Yoshihiko Maehara, Tatsuro Okamoto, Shinkichi Takamori, Taichi Matsubara, Gouji Toyokawa, Naoki Haratake, Masakazu Katsura, Yoshinao Oda, Takaki Akamine, Fumihiro Shoji |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Lung Neoplasms DNA Mutational Analysis medicine.disease_cause Polymerase Chain Reaction B7-H1 Antigen 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans Pulmonary metastasis 030212 general & internal medicine Epidermal growth factor receptor Lung cancer Aged Neoplasm Staging Aged 80 and over Mutation biology business.industry DNA Neoplasm Middle Aged medicine.disease Immunohistochemistry ErbB Receptors Gene Expression Regulation Neoplastic Egfr mutation 030220 oncology & carcinogenesis Asian population biology.protein Female Surgery Cardiology and Cardiovascular Medicine business Programmed death |
| Zdroj: | The Annals of Thoracic Surgery. 105:448-454 |
| ISSN: | 0003-4975 |
| Popis: | Background Little is known about the programmed death-ligand 1 (PD-L1) expression in multifocal lung cancer, such as the expression in multiple primary lung cancer and pulmonary metastasis. In this translational study, we investigated PD-L1 expression and its relationship with the epidermal growth factor receptor ( EGFR ) mutation status in resected multifocal lung cancer. Methods The PD-L1 expression in 152 samples of multifocal lung cancer from 59 patients was evaluated by an immunohistochemical analysis. Results Among the 152 lung cancer lesions of 59 patients, PD-L1 expression was observed in 29 lesions (19.1%) of 20 patients (33.9%). Among 43 patients with 112 multiple primary lung cancer lesions, 15 lesions (13.4%) of 13 patients (30.2%) were PD-L1 positive; and among 16 patients with 40 pulmonary metastatic lesions, 14 lesions (35.0%) of 7 patients (43.8%) were PD-L1-positive. Among 43 patients with multiple primary lung cancer, there was disagreement of PD-L1 expression in 12 patients (27.9%, κ = 0.104). On the contrary, among 16 patients with pulmonary metastasis, disagreement of PD-L1 expression was observed only in 1 patient (6.3%, κ = 0.871). In pulmonary metastatic lesions, the frequency of PD-L1 positivity among lesions with wild-type EGFR was significantly higher than among lesions with mutated EGFR (66.7% versus 0%: p Conclusions This study provides important evidence of higher levels of agreement of PD-L1 expression in pulmonary metastasis compared with in multiple primary lung cancer, and high positivity of PD-L1 expression in pulmonary metastatic lesions with wild-type EGFR in an Asian population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|