Association of serum uric acid with visceral, subcutaneous and hepatic fat quantified by magnetic resonance imaging
| Autor: | Susanne Rospleszcz, Fabian Bamberg, Katharina Müller-Peltzer, Konstantin Strauch, Ditjon Dermyshi, Annette Peters |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Waist Epidemiology Population Subcutaneous Fat lcsh:Medicine Adipose tissue Hyperuricemia Intra-Abdominal Fat 030204 cardiovascular system & hematology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diabetes mellitus Internal medicine medicine Humans lcsh:Science education Aged education.field_of_study Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Confounding Diagnostic markers Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Obesity Uric Acid Cross-Sectional Studies 030104 developmental biology Endocrinology Liver chemistry Uric acid Female lcsh:Q business |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Elevated serum uric acid (SUA) is associated with a variety of medical conditions, such as hypertension, diabetes and obesity. Analyses investigating uric acid and obesity were primarily conducted using anthropometric measures like BMI and waist circumference. However, different adipose tissue depots might be differentially affected in uric acid metabolism. We analyzed the relation of SUA with visceral, subcutaneous and hepatic fat as quantified by Magnetic Resonance Imaging in N = 371 individuals from a cross-sectional sample of a population-based cohort. Associations of SUA and fat depots were calculated by regressions adjusted for potential confounders. We found that SUA was correlated with all fat measures (e.g. Pearson’s r between SUA and hepatic fat: 0.50, 95%-CI: 0.42, 0.57). Associations with visceral and hepatic fat, but not with subcutaneous fat, remained evident after adjustment for anthropometric measures (e.g. visceral fat: β = 0.51 l, 95%-CI: 0.30 l, 0.72 l). In conclusion, these results show how different adipose tissue compartments are affected by SUA to varying degrees, thus emphasizing the different physiological roles of these adipose tissues in uric acid metabolism. |
| Databáze: | OpenAIRE |
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