Expression of human DNA mismatch-repair protein, hMSH2, in patients with oral lichen planus
| Autor: | Ying‑Huai Zhang, Yong Chen, Hao‑Bo Li, Hui‑Zhen Chen |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities mismatch repair genes hMSH2 Gastroenterology oral lichen planus Immunology and Microbiology (miscellaneous) stomatognathic system Internal medicine Medicine Oncogene business.industry Cancer nutritional and metabolic diseases General Medicine Mismatch Repair Protein Articles medicine.disease Molecular medicine digestive system diseases stomatognathic diseases Immunology immunohistochemistry Biomarker (medicine) Immunohistochemistry DNA mismatch repair Oral lichen planus business |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-0981 |
| Popis: | hMSH2 is one of the human DNA mismatch repair genes that plays an important role in reducing mutations and maintaining genomic stability. The aim of the present study was to detect the expression and significance of hMSH2 protein in patients with oral lichen planus (OLP). The expression levels of hMSH2 in the OLP group (n=51) and control group with normal oral mucosa (NM; n=40) were detected using an immunohistochemical method and subsequently assessed. The positive rate of hMSH2 expression in the OLP group was 52.94%, while the rate was 80% in the control group, exhibiting a statistically significant difference (χ2=7.1993; P0.05). In conclusion, the protein expression levels of hMSH2 in the OLP tissues were significantly reduced as compared with that in the NM tissues, indicating that hMSH2 plays a role in the development of OLP. Therefore, hMSH2 may be used as a biomarker for evaluating the cancer risk of patients with OLP. |
| Databáze: | OpenAIRE |
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