Treatment of Renal Tumors by Percutaneous Ultrasound-Guided Radiofrequency Ablation Using a Multitined Electrode: Effectiveness and Complications

Autor: M. Unda, Jose I. Iriarte, Rosa Zabala, José Luis del Cura
Rok vydání: 2010
Předmět:
Zdroj: European Urology. 57:459-465
ISSN: 0302-2838
DOI: 10.1016/j.eururo.2009.11.025
Popis: Background Radiofrequency ablation (RFA) is a minimally aggressive, therapeutic alternative for renal tumors. It can be an alternative to nephrectomy in patients with previous nephrectomy, bilateral tumors, von Hippel-Lindau disease, or small renal carcinomas and in those with contraindications for surgery. Objective To assess the effectiveness of the treatment of renal tumors by RFA in the short and medium term and to identify the possible complications and the factors that determine therapeutic success. Design, setting, and participants A retrospective review of patients with renal tumors treated with RFA between May 2005 and December 2008 was performed in a tertiary academic hospital. Patients were selected among those with previous nephrectomy, bilateral neoplasms, von Hippel-Lindau disease, surgical risk, comorbidity, advanced age, or patient's refusal to surgery. Tumors with evidence of extrarenal extension were excluded. Patients were followed up for 10–50 mo using computed tomography and magnetic resonance imaging. Intervention Ultrasound-guided RFA was performed on 65 tumors (range: 1.2–5.3cm) of 58 patients using multitined electrodes. Measurements Incomplete ablation rate, therapeutic success rate, and complications rate. Results and limitations Therapeutic success was achieved in 59 of 65 tumors (91%): 53 in a single session, 5 in two sessions, and 1 in three sessions. A significant relationship was observed between size and growth pattern of the tumor and both therapeutic success and incomplete ablation rates. Therapeutic success in tumors >5cm was 60%. Complications were detected in 10 patients (13%); 5% were considered major complications. Limitations include the lack of pathologic studies to confirm a complete ablation and the lack of a control group to compare with the results of those who underwent nephrectomy. Conclusions RFA is safe and effective in renal tumors. Corticomedullary lesions and tumors >3cm have greater possibility of incomplete ablation. In tumors >5cm, RFA has a significant failure rate.
Databáze: OpenAIRE
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