Hypolipidemic effects of different angiocarp parts ofAlpinia zerumbet

Autor:	Robert Y. Peng, Kuan Chou Chen, Chao Ming Chuang, Hui Er Wang, Chiung Chi Peng
Rok vydání:	2011
Předmět:	Male Lipoproteins Pharmaceutical Science Context (language use) Methylation Gas Chromatography-Mass Spectrometry law.invention Feces chemistry.chemical_compound law Cricetinae Drug Discovery Oils Volatile Animals Alpinia zerumbet Food science Essential oil Hypolipidemic Agents Pharmacology chemistry.chemical_classification Glutathione Peroxidase Mesocricetus biology Triglyceride Superoxide Dismutase Hydrolysis Glutathione peroxidase Fatty Acids Alpinia General Medicine Lipid Metabolism biology.organism_classification Diet Cholesterol Liver Complementary and alternative medicine Biochemistry chemistry Fruit Seeds Molecular Medicine Zingiberaceae Chemical and Drug Induced Liver Injury Drugs Chinese Herbal Lipoprotein
Zdroj:	Pharmaceutical Biology. 49:1257-1264
ISSN:	1744-5116 1388-0209
DOI:	10.3109/13880209.2011.589856
Popis:	In utilization of Alpinia zerumbet (Pers.) Burtt and Smith (Zingiberaceae) (AZ), usually the angiocarps are discarded without further use.We speculate whether the angiocarps could show hypolipidemic effect.Several diets were prepared: Alpinia seed powder (ASP); Alpinia seed powder/husk (ASH): 40/60; and Alpinia seed essential oil (ASO): 0.01-0.10%. Sprague-Dawley rats divided into 11 groups were fed these diets for 8 weeks and tested for the hypolipidemic bioactivity.The fecal neutral cholesterol excretion was increased, and the serum total triglyceride (TG) was significantly reduced from 153.7 mg/dL in the high-fat group (H) to 114.3-119.8 mg/dL by ASO; to 116.3-147.9 mg/dL by ASP; and to 116.2-145.3 mg/dL by ASH. Activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX) were almost unaffected. The high-density lipoprotein (HDL) levels were mostly raised by ASO to 180.3-200.8 mg/dL. The lowdensity lipoprotein (LDL) levels were mostly reduced to 66.8-82.6 mg/dL by ASH. The level of arachidonic acid was mostly raised to 0.50-0.60% by ASO, compared with 0.37% of group H. More importantly, the significant reduction in hepatic TG and total cholesterol (TC) implicated a crucial liver protective effect.ASP and ASH consisted of high crude-fiber content, while ASO consisted of seed essential oil. Both the seed essential oil and the whole powder of AZ previously had been reported to possess potent hypolipidemic bioactivity. Conclusively, the hypolipidemic effect can be attributed to the combined effect of the essential oil and the crude fiber.
Databáze:	OpenAIRE
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