Distribution of hepatitis C virus genotypes among intravenous drug users in the Çukurova region of Turkey
| Autor: | Engin Altintaş, Orhan Sezgin, Süveyda Gözüküçük, Mahmut Bakır Koyuncu, Enver Üçbilek, Alper Akdağ, Durdane Midikli, Bahri Abayli, Osman Özdoğan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genotype Turkey Hepatitis C virus 030106 microbiology HCV genotypes Hepacivirus medicine.disease_cause Drug Users 03 medical and health sciences 0302 clinical medicine Humans Medicine 030212 general & internal medicine Substance Abuse Intravenous Dominance (genetics) Intravenous drug business.industry Hepatitis C HCV genotypes intravenous drug users Normal population General Medicine Hepatitis C Virology RNA Viral business |
| Zdroj: | Volume: 46, Issue: 1 66-71 Turkish Journal of Medical Sciences |
| ISSN: | 1303-6165 1300-0144 |
| DOI: | 10.3906/sag-1411-169 |
| Popis: | Background/aim: The most common hepatitis C virus (HCV) genotype in Turkey is genotype 1. However, there has not been a study about the distribution of HCV genotypes among intravenous drug users (IVDUs) in the Çukurova region of Turkey. This study was planned to understand if there is a difference between IVDUs and the normal population. Materials and methods: Between May 2010 and May 2014, anti-HCV positive IVDUs who applied to the 6 hospitals in the Çukurova region of Turkey were included in this study. Their HCV genotypes were studied. Results: Ninety-seven anti-HCV positive IVDUs were screened in terms of HCV RNA and genotype. Ten were excluded from the study because their HCV RNA results were negative. Fifty-one of the 87 patients (58.6%) had genotype 3. Genotype 2 was detected in 26 (29.9%) and genotype 1 was detected in 10 (11.5%) patients. Conclusion: HCV genotypes seem to be different between the normal population and IVDUs according to studies worldwide. Among IVDUs, we detected a dominance of genotype 3 and genotype 2, which is apparently different from the normal population. The reason for this difference can be simply explained by infection through shared needles. However, there may still be a different immunological response in IVDUs, the investigation of which may lead to further studies. |
| Databáze: | OpenAIRE |
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