An Evaluation of the Use of Dried Blood Spots from Newborn Screening for Monitoring the Prevalence of Cocaine Use among Childbearing Women
| Autor: | Kenneth A. Pass, W. Harry Hannon, Roger W. Rochat, Mary K. Powell, Cynthia Ferre, Louise Martin, Mary D. Brantley, Paul M. Fernhoff, L. Omar Henderson, Eric J. Sampson, John T. Bernert, Elizabeth Franko |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Georgia Population Prevalence Pilot Projects Biochemistry chemistry.chemical_compound Neonatal Screening Cocaine Pregnancy Humans Medicine education Dried blood Blood Specimen Collection education.field_of_study Newborn screening business.industry Obstetrics Infant Newborn medicine.disease Dried blood spot Substance Abuse Detection Substance abuse chemistry Evaluation Studies as Topic Cocaine use Benzoylecgonine Female business |
| Zdroj: | Biochemical and Molecular Medicine. 61:143-151 |
| ISSN: | 1077-3150 |
| DOI: | 10.1006/bmme.1997.2609 |
| Popis: | A collaborative March of Dimes study was designed to examine the utility of dried blood spot (DBS) materials routinely collected from newborns as a source for monitoring cocaine exposure and to assess the prevalence of cocaine use among childbearing women in Georgia. We used a modified urinary radioimmunoassay (RIA) to anonymously detect the cocaine metabolite benzoylecgonine (BE) in DBSs. Extensive efforts were undertaken to assure absolute nonlinkage of BE data to any individual. The positive results found by RIA were confirmed by a mass spectrometry (MS) method specifically developed to detect BE in DBSs. BE was measured in 23,141 DBSs collected during 2 months of routine newborn screening in Georgia. A good correlation was observed for RIA results versus MS results (r2= 0.97). The estimated minimal statewide BE prevalence was 4.8 per 1000 childbearing women. We demonstrated that immunoassay testing for cocaine without confirmatory testing can yield falsely elevated prevalence rates. When proper confirmatory testing is done, DBSs are a valuable source for population-based monitoring of substance abuse among childbearing women. |
| Databáze: | OpenAIRE |
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