Effect of eating on plasma radical-trapping antioxidant activity (TRAP) in patients with cirrhosis
| Autor: | Carlo Fabris, Ettore Bartoli, Nadia Bortolotti, Edmondo Falleti, Mario Pirisi, Edda Federico, Giorgio Soardo, Fabio Gonano |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Blood Glucose
Liver Cirrhosis Male Alcoholic liver disease medicine.medical_specialty Cirrhosis Antioxidant Radical trapping Free Radicals medicine.medical_treatment Clinical Biochemistry Antioxidants Trap (computing) Liver disease Eating Liver Cirrhosis Alcoholic Reference Values Internal medicine medicine Humans Insulin In patient Inverse correlation Triglycerides Chemistry General Medicine Fasting Middle Aged medicine.disease Endocrinology Case-Control Studies Female |
| Zdroj: | Clinical biochemistry. 32(6) |
| ISSN: | 0009-9120 |
| Popis: | Objectives: To ascertain the effects of eating on plasma antioxidant capacity in patients with liver disease. Design and methods: Eighteen cirrhotic patients were compared to 18 age and sex-matched controls. TRAP was measured by a fluorometric assay after a 12 h fast, and 60, 120, and 180 min after the study participants had taken a drink formula food. Results: In the fasting state, TRAP was higher in patients with alcoholic cirrhosis (847 ± 39 μmol/L, mean ± SEM) in comparison to patients with viral cirrhosis (653 ± 41) and to controls (758 ± 26) (p < 0.005). In cirrhotic patients, TRAP did not change in the post-absorptive state. In controls, TRAP decreased progressively, to a value of 719 ± 21 (p < 0.02), and the AUC of the Δ-values of TRAP and of plasma insulin showed an inverse correlation (r = −0.52, p < 0.05). Conclusions: In normal subjects, but not in cirrhotics, TRAP decreases in the post-absorptive state, probably in relationship with the activation of metabolic pathways. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect