Phytosterol metabolism in plant positive-strand RNA virus replication
| Autor: | Teresa Altabella, Karla Ramirez-Estrada, Albert Ferrer |
|---|---|
| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat de Catalunya |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
RNA virus
Plant biotic stress Efecte de l'estrès sobre les plantes biology Fitosterols RNA RNA-dependent RNA polymerase Phytosterols Plant Science General Medicine Plantes Plants biology.organism_classification Genome Virus Cell biology Viral replication Plant virus Effect of stress on plants Glycosylated sterols Endomembrane system Agronomy and Crop Science |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | The genome of most plant viruses consists of a single positive-strand of RNA (+ ssRNA). Successful replication of these viruses is fully dependent on the endomembrane system of the infected cells, which experiences a massive proliferation and a profound reshaping that enables assembly of the macromolecular complexes where virus genome replication occurs. Assembly of these viral replicase complexes (VRCs) requires a highly orchestrated interplay of multiple virus and co-opted host cell factors to create an optimal microenvironment for efficient assembly and functioning of the virus genome replication machinery. It is now widely accepted that VRC formation involves the recruitment of high levels of sterols, but the specific role of these essential components of cell membranes and the precise molecular mechanisms underlying sterol enrichment at VRCs are still poorly known. In this review, we intend to summarize the most relevant knowledge on the role of sterols in ( +)ssRNA virus replication and discuss the potential of manipulating the plant sterol pathway to help plants fight these infectious agents. This work was supported by grants AGL2017-88842-R from FEDER/Ministerio de Ciencia, Innovación y Universidades-Agencia Estatal de Investigación (Spain), 2017SGR710 from the Generalitat de Catalunya, and by the CERCA Programme of the Generalitat de Catalunya. We also acknowledge financial support from the Spanish Ministerio de Economía y Competitividad-Agencia Estatal de Investigación through the “Severo Ochoa Programme for Centres of Excellence in R&D” CEX2019-000902-S. |
| Databáze: | OpenAIRE |
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