Platelet Survival in Hematology Patients Assessed by the Corrected Count Increment and Other Formulas
| Autor: | Karina Elizabeth Vázquez-Hernández, José Carlos Jaime-Pérez, Rosario Salazar-Riojas, David Gómez-Almaguer, Lucía T. Fernández, Raúl Alberto Jiménez-Castillo |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Hematology business.industry Platelet recovery Plateletpheresis General Medicine 030204 cardiovascular system & hematology medicine.disease Gastroenterology Sepsis 03 medical and health sciences 0302 clinical medicine Apheresis Platelet transfusion Internal medicine Platelet survival medicine Platelet business 030215 immunology |
| Zdroj: | American Journal of Clinical Pathology. 150:267-272 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | OBJECTIVES To compare the performance of the corrected count increment (CCI) and three other formulas to assess 24-hour posttransfusion platelet survival in hematology patients. METHODS Twenty-four-hour posttransfusion platelet counts were analyzed after apheresis platelet transfusion. Platelet increment (PI), percent platelet recovery (PPR), and percentage platelet increment (PPI) were compared with CCI by receiver operating characteristic analysis. Clinical factors that influence platelet survival were assessed by logistic regression. RESULTS In total, 142 apheresis platelet transfusions in 85 hematology patients were studied. Mean (SD) CCI at 24 hours was 11,869 (10,125). Compared with CCI, the sensitivity of other formulas ranged from 89.4% to 95.7% and specificity from 94.7% to 100%. Cutoff values were 15.7 × 103/µL for PI, 11.4% for PPR, and 17% for PPI. For ABO-compatible vs incompatible transfusions, CCI was 14,070/µL vs 9,176/µL (P = .007). Negative factors for all formulas were sepsis, hypotension, and amphotericin B. CONCLUSIONS PI, PPR, and PPI are comparable to CCI for assessing 24-hour platelet survival. |
| Databáze: | OpenAIRE |
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