| Autor: |
Anna Gusakova, Tatiana Suslova, Maria Kercheva, Irina Kologrivova, Tamara Ryabova, Vyacheslav Ryabov |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of medical biochemistry. 41(4) |
| ISSN: |
1452-8258 |
| Popis: |
The study of laboratory biomarkers that reflect the development of adverse cardiovascular events in the postinfarction period is of current relevance. The aim of the present study was evaluation of oncostatin M (OSM) concentration changes in the early and late stages of myocardial infarction and evaluation of the possibility of its use in prediction of adverse left ventricular (LV) remodeling in patients with myocardial infarction with ST-elevated segment (STEMI).The study involved 31 patients with STEMI admitted in the first 24 hours after the onset of MI and 30 patients with chronic coronary artery disease as a control group. Echocardiographic study was performed on day 3 and in 6 months after STEMI. The serum levels of biomarkers were evaluated on the day of hospital admission and 6 months after MI using multiplex immunoassay.OSM level increased during the first 24 h after the onset of the disease, with the following decrease in 6 months. OSM concentration at admission had correlated with echocardiography parameters and Nt-proBNP, troponin I, CK-MB levels. Our study has demonstrated association of the increased levels of OSM at the early stages of STEMI with development of the adverse LV remodeling in 6 months after the event.Elevation of OSM levels in the first 24 h after STEMI is associated with the development of the adverse LV remodeling in the long-term post-infarction period.Proučavanje laboratorijskih biomarkera koji odražavaju razvoj neželjenih kardiovaskularnih događaja u periodu nakon infarkta je trenutno relevantno. Cilj ove studije bio je procena promene koncentracije onkostatina M (OSM) u ranim i kasnim stadijumima infarkta miokarda i procena mogućnosti njegove upotrebe u predviđanju neželjenog remodeliranja leve komore (LV) kod pacijenata sa infarktom miokarda sa ST-povišenim segmentom (STEMI).U istraživanju je učestvovao 31 pacijent sa STEMI primljenim u prva 24 sata od pojave IM i 30 pacijenata sa hroničnom koronarnom bolešću kao kontrolna grupa. Ehokardiografska studija je urađena 3. dana i 6 meseci nakon STEMI. Nivoi biomarkera u serumu su procenjeni na dan prijema u bolnicu i 6 meseci nakon IM primenom multipleksnog imunoeseja.Nivo OSM je porastao tokom prva 24 h od pojave bolesti, sa sledećim smanjenjem za 6 meseci. Koncentracija OSM pri prijemu je bila u korelaciji sa parametrima ehokardiografije i nivoima Nt-proBNP, troponina I, CK-MB. Naša studija je pokazala povezanost povećanih nivoa OSM u ranim fazama STEMI sa razvojem neželjenog remodeliranja LV u 6 meseci nakon događaja.Povišenje nivoa OSM u prva 24 h nakon STEMI je povezano sa razvojem neželjenog remodeliranja LV u dugotrajnom postinfarktnom periodu. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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