Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception
| Autor: | Julia Rhyins, Alan J. Emanuel, Nicole Neubarth, Mark W. Springel, Amira Abdelaziz, Yin Liu, Michelle M. DeLisle, David D. Ginty, Qiyu Zhang, Christopher D. Harvey, Wade G. Regehr, Jan Drugowitsch, Stuart J. Cattel, Chong Guo, Lauren L. Orefice, Brendan P. Lehnert, Michael Iskols, Soo Joong Kim, Annie Handler |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Biology Tactile stimuli Merkel Cells Mice medicine Glabrous skin Animals Electron microscopic Mice Knockout Multidisciplinary Membrane Glycoproteins Extramural Brain-Derived Neurotrophic Factor Protein-Tyrosine Kinases Sensorimotor control Mechanoreceptor Mice Inbred C57BL Microscopy Electron medicine.anatomical_structure Touch Perception Receptive field Touch Female Epidermis Neuroscience Signal Transduction |
| Zdroj: | Science (New York, N.Y.). 368(6497) |
| ISSN: | 1095-9203 |
| Popis: | Secrets of Meissner corpuscles The Meissner corpuscle, a mechanosensory end organ, was discovered more than 165 years ago and has since been found in the glabrous skin of all mammals, including that on human fingertips. Although prominently featured in textbooks, the function of the Meissner corpuscle is unknown. Neubarth et al. generated adult mice without Meissner corpuscles and used them to show that these corpuscles alone mediate behavioral responses to, and perception of, gentle forces (see the Perspective by Marshall and Patapoutian). Each Meissner corpuscle is innervated by two molecularly distinct, yet physiologically similar, mechanosensory neurons. These two neuronal subtypes are developmentally interdependent and their endings are intertwined within the corpuscle. Both Meissner mechanosensory neuron subtypes are homotypically tiled, ensuring uniform and complete coverage of the skin, yet their receptive fields are overlapping and offset with respect to each other. Science , this issue p. eabb2751 ; see also p. 1311 |
| Databáze: | OpenAIRE |
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