Biomechanics in bone tissue engineering
Autor: | Dominique Pioletti |
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Rok vydání: | 2010 |
Předmět: |
load-bearing application
Scaffold Computer science Biomedical Engineering Mechanical integrity Mechanical-Properties Bioengineering Biophysical Principles Models Biological biomechanics Bone and Bones Bone tissue engineering Mesenchymal Stem-Cells Biomechanical Phenomena Tissue engineering bone scaffold Regeneration Humans Mechanotransduction Fluid-Flow mechanotransduction Osteogenic Differentiation Scaffolds Tissue Engineering Regeneration (biology) Biomechanics Finite-Element General Medicine Computer Science Applications Human-Computer Interaction In-Vitro Trabecular Bone Biomedical engineering |
Zdroj: | Scopus-Elsevier |
ISSN: | 1476-8259 1025-5842 |
DOI: | 10.1080/10255841003630660 |
Popis: | Biomechanics may be considered as central in the development of bone tissue engineering. The initial mechanical aspects are essential to the outcome of a functional tissue engineering approach; so are aspects of interface micromotion, bone ingrowths inside the scaffold and finally, the mechanical integrity of the scaffold during its degradation. A proposed view is presented herein on how biomechanical aspects can be synthesised and where future developments are needed. In particular, a distinction is made between the mechanical and the mechanotransductional aspects of bone tissue engineering: the former could be related to osteoconduction, while the latter may be correlated to the osteoinductive properties of the scaffold. This distinction allows biomechanicians to follow a strategy in the development of a scaffold having not only mechanical targets but also incorporating some mechanotransduction principles. |
Databáze: | OpenAIRE |
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