P-5 HEPATITIS E VIRUS INFECTION INCREASES THE RISK OF DIABETES AND MORTALITY IN HCV infected patients
| Autor: | João Renato Rebello Pinho, Flair José Carrilho, Ryan YukimatsuTanigawa, Alberto Queiroz Farias, Patricia Momoyo Yoshimura Zitelli, Mario G. Pessoa, Michele Soares Gomes-Gouvêa, Daniel Ferraz de Campos Mazo, Julio M. Singer, Venancio Avancini Ferreira Alves, Claudia Pms de Oliveira |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
viruses Hepatitis C virus Seroprevalence Specialties of internal medicine Chronic hepatitis C medicine.disease_cause Gastroenterology Virus Serology Liver disease Diabetes mellitus Hepatitis E virus Internal medicine medicine Hepatology business.industry virus diseases Hepatitis A General Medicine medicine.disease Liver fibrosis Cirrhosis digestive system diseases Hepatitis E RC581-951 Coinfection business |
| Zdroj: | Annals of Hepatology, Vol 24, Iss, Pp 100371-(2021) |
| ISSN: | 1665-2681 |
| DOI: | 10.1016/j.aohep.2021.100371 |
| Popis: | Background: Co-infection with hepatitis A or B viruses may aggravate liver injury in hepatitis C virus (HCV) infected patients. However, few studies have assessed hepatitis E virus (HEV) and HCV coinfection. Aim: Our goal was to assess the prevalence and impact of HEV infection among Brazilian patients with chronic hepatitis C virus. Methods: This cross-sectional study included adult patients with chronic HCV infection, naïve to antiviral therapy. Prospectively and consecutively recruited from January 2013 to March 2016. 181 patients were enrolled and HEV serology and PCR were performed for all patients. Results: Seropositivity for anti-HEV IgG was detected in 22 (12.0%) and for anti-HEV IgM in 3 (1.6%) patients. HEV RNA was inconclusive in 9 (4.9%) and undetectable in the remaining cases. HEV serology positive cases had more severe liver disease, characterized by liver fibrosis ≥3 vs ≤2 (p |
| Databáze: | OpenAIRE |
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