Associations between androgen and Vitamin D receptor microsatellites and postmenopausal breast cancer
| Autor: | Håkan Melhus, Fredrik Stiger, Elisabete Weiderpass, Maria Branting, Cecilia Magnusson, Sara Wedrén, John A. Baron, Keith Humphreys, Ingemar Persson, Andreas Kindmark |
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| Rok vydání: | 2007 |
| Předmět: |
Risk
medicine.medical_specialty Epidemiology Breast Neoplasms Calcitriol receptor Polymorphism Single Nucleotide Breast cancer Risk Factors Internal medicine Genotype Vitamin D and neurology Medicine Humans Genetic Predisposition to Disease Allele Alleles Aged Sweden business.industry Case-control study Odds ratio Middle Aged medicine.disease Androgen receptor Postmenopause Endocrinology Oncology Receptors Androgen Case-Control Studies Receptors Calcitriol Female business Microsatellite Repeats |
| Zdroj: | Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 16(9) |
| ISSN: | 1055-9965 |
| Popis: | We investigated the association between polymorphism in the androgen receptor (AR) and vitamin D receptor (VDR) genes and breast cancer risk in a large population-based case-control study of genetically homogenous Swedish women. We successfully determined both AR CAGn and VDR An genotype in 1,502 women with invasive breast cancer and in 1,510 control women. We did not find any associations between AR or VDR microsatellite lengths and breast cancer when we used a priori determined cutoffs (≤21 or ≥22 repeats for AR and ≤18 or ≥19 for VDR) to define long and short alleles. There was statistically significant interaction between VDR genotype and parity, such that women with two short alleles had a halved risk for breast cancer, irrespective of parity, compared with nulliparous women with two long alleles. Homozygosity for the long VDR allele was associated with a more advanced clinical stage at diagnosis. In exploratory analyses, we determined cutoffs based on visual inspection of distributions of allele lengths among cases and controls and found that women carrying two alleles with |
| Databáze: | OpenAIRE |
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