Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders
| Autor: | Neal R. Klauer, Tsung-Ping Su, Nicole E De Credico, Shang-Yi Tsai, Michael J. Pokrass |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Narcotic Antagonists Cellular differentiation Clinical Biochemistry Article Drug Delivery Systems Drug Discovery medicine Animals Humans Receptors sigma Receptor Psychiatry Pharmacology Sigma-1 receptor biology Microglia business.industry Mental Disorders Endoplasmic reticulum Neurodegenerative Diseases Transmembrane protein medicine.anatomical_structure Chaperone (protein) biology.protein Unfolded protein response Molecular Medicine business Molecular Chaperones |
| Zdroj: | Expert Opinion on Therapeutic Targets. :1-16 |
| ISSN: | 1744-7631 1472-8222 |
| Popis: | Sigma-1 receptors (Sig-1Rs) are molecular chaperones that reside mainly in the endoplasmic reticulum (ER) but exist also in the proximity of the plasma membrane. Sig-1Rs are highly expressed in the CNS and are involved in many cellular processes including cell differentiation, neuritogenesis, microglia activation, protein quality control, calcium-mediated ER stress and ion channel modulation. Disturbance in any of the above cellular processes can accelerate the progression of many neurological disorders; therefore, the Sig-1R has been implicated in several neurological diseases.This review broadly covers the functions of Sig-1Rs including several neurodegenerative disorders in humans and drug addiction-associated neurological disturbance in the case of HIV infection. We discuss how several Sig-1R ligands could be utilized in therapeutic approaches to treat those disorders.Emerging understanding of the cellular functions of this unique transmembrane chaperone may lead to the use of new agents or broaden the use of certain available ligands as therapeutic targets in those neurological disorders. |
| Databáze: | OpenAIRE |
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