Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurgence of Serogroup W, Niger, 2015

Autor: Cecilia B, Kretz, Adam C, Retchless, Fati, Sidikou, Bassira, Issaka, Sani, Ousmane, Stephanie, Schwartz, Ashley H, Tate, Assimawè, Pana, Berthe-Marie, Njanpop-Lafourcade, Innocent, Nzeyimana, Ricardo Obama, Nse, Ala-Eddine, Deghmane, Eva, Hong, Ola Brønstad, Brynildsrud, Ryan T, Novak, Sarah A, Meyer, Odile Ouwe Missi, Oukem-Boyer, Olivier, Ronveaux, Dominique A, Caugant, Muhamed-Kheir, Taha, Xin, Wang, Goumbi, Kadade
Přispěvatelé: Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), Réseau International des Instituts Pasteur (RIIP), World Health Organization [Niamey], Agence de Médecine Préventive, Institut Pasteur [Paris] (IP), Norwegian Institute of Public Health [Oslo] (NIPH), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), This work was funded by CDC., Members of the Niger Response Team who contributed to this study: Jennifer D. Thomas, Fang Hu, Brian H. Harcourt, Melissa J. Whaley, How-Yi Chang, Laurel Thompson Jenkins, Susanna E. Schmink (CDC), Didier Mounkoro, Oubote Abodji (Agence de Médecine Préventive), Jibir Zanguina, Aichatou Moussa, Mariama Sambo (CERMES), and Maman Zaneidou and Goumbi Kadade (Direction de la Surveillance et de la Riposte aux Epidémies)., Institut Pasteur [Paris]
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
MESH: Neisseria meningitidis
Serogroup C/genetics
MESH: Meningitis
Meningococcal/microbiology
MESH: Sequence Analysis
DNA
Epidemiology
MESH: Neisseria meningitidis
Serogroup C/isolation & purification
lcsh:Medicine
MESH: Antigens
Bacterial/genetics
Neisseria meningitidis
Serogroup C
Neisseria meningitidis
Meningococcal meningitis
MESH: Genome
Bacterial
Genome
Communicable Diseases
Emerging
meningitis belt
MESH: Drug Resistance
Bacterial/genetics
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
MESH: Communicable Diseases
Emerging
Niger
MESH: Genetic Variation
bacteria
MESH: Phylogeny
Phylogeny
Phylogenetic tree
MESH: Molecular Typing
Epidemic season
Neisseria meningitidis serogroup C
3. Good health
Infectious Diseases
whole-genome sequencing
MESH: Neisseria meningitidis/genetics
Microbiology (medical)
DNA
Bacterial
Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurging Serogroup W
Niger
2015
MESH: Meningitis
Meningococcal/epidemiology
Biology
Meningitis
Meningococcal
lcsh:Infectious and parasitic diseases
Microbiology
03 medical and health sciences
Genetic Evolution
Drug Resistance
Bacterial
parasitic diseases
Humans
lcsh:RC109-216
Serotyping
Epidemics
MESH: Epidemics
Antigens
Bacterial
[SDV.GEN]Life Sciences [q-bio]/Genetics
MESH: Humans
Research
lcsh:R
MESH: Niger/epidemiology
Outbreak
Genetic Variation
MESH: Serotyping
Sequence Analysis
DNA
Virology
MESH: DNA
Bacterial
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Molecular Typing
030104 developmental biology
MESH: Neisseria meningitidis/isolation & purification
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Genome
Bacterial
Zdroj: Emerging Infectious Diseases
Emerging Infectious Diseases, 2016, 22 (10), pp.1762-1768. ⟨10.3201/eid2210.160468⟩
Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, 22 (10), pp.1762-1768. ⟨10.3201/eid2210.160468⟩
Emerging Infectious Diseases, Vol 22, Iss 10, Pp 1762-1768 (2016)
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid2210.160468⟩
Popis: International audience; In 2015, Niger reported the largest epidemic of Neisseria meningitidis serogroup C (NmC) meningitis in sub-Saharan Africa. The NmC epidemic coincided with serogroup W (NmW) cases during the epidemic season, resulting in a total of 9,367 meningococcal cases through June 2015. To clarify the phylogenetic association, genetic evolution, and antibiotic determinants of the meningococcal strains in Niger, we sequenced the genomes of 102 isolates from this epidemic, comprising 81 NmC and 21 NmW isolates. The genomes of 82 isolates were completed, and all 102 were included in the analysis. All NmC isolates had sequence type 10217, which caused the outbreaks in Nigeria during 2013-2014 and for which a clonal complex has not yet been defined. The NmC isolates from Niger were substantially different from other NmC isolates collected globally. All NmW isolates belonged to clonal complex 11 and were closely related to the isolates causing recent outbreaks in Africa.
Databáze: OpenAIRE
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