Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus

Autor:	Xuan Feng, David O'Hagan, Davide Bello
Přispěvatelé:	EPSRC, University of St Andrews. School of Chemistry, University of St Andrews. EaSTCHEM, University of St Andrews. Biomedical Sciences Research Complex
Rok vydání:	2021
Předmět:	Nucleocidin Chemistry Stereochemistry QH301 Biology General Chemical Engineering NDAS Fluorine containing General Chemistry QD Chemistry Isolation (microbiology) Adenosine Biosynthetic enzyme QH301 Streptomyces calvus medicine QD medicine.drug
Zdroj:	RSC Advances. 11:5291-5294
ISSN:	2046-2069
Popis:	Funding: We thank EPSRC (EP/R013799/1) for a grant (DB) and the University of St Andrews for a Studentship (XF). The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts. Publisher PDF
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9175153c65e3999307d001119a3f7b https://doi.org/10.1039/d1ra00235j Zobrazit plný text záznamu