Functional asymmetry of the cerebral hemispheres: its role in the pathogenesis of ectromelia and melanoma in (CBAxC57BL/6)F1 mice
| Autor: | Vladimir A. Kozlov, V. V. Abramov, E. L. Gelfgat, Irina A. Gontova, I. M. Ignatiev |
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| Rok vydání: | 2007 |
| Předmět: |
Nervous system
Male Pathology medicine.medical_specialty Melanoma Experimental Biology Motor Activity Functional Laterality Pathogenesis Ectromelia Subcutaneous injection Mice medicine Animals Ectromelia Infectious Dominance (genetics) General Neuroscience Melanoma Ectromelia virus medicine.disease biology.organism_classification Mice Inbred C57BL medicine.anatomical_structure Immunology Mice Inbred CBA Functional asymmetry Neoplasm Transplantation |
| Zdroj: | Neuroscience and behavioral physiology. 40(7) |
| ISSN: | 1573-899X |
| Popis: | The aim of the present work was to identify the role of functional asymmetry in the cerebral hemispheres in the pathogenesis of infectious and oncological pathology in (CBAxC57BL/6)F1 mice. Mice with lefthemisphere dominance of motor functions (“right-handers”) were found to be more resistant to infection with ectromelia virus and to show slower growth of tumors after subcutaneous injection of B-16 melanoma than animals with right-hemisphere dominance of motor control (“left-handers”). Thus, this report provides the first evidence for the role of functional asymmetry of the nervous system in the pathogenesis of ectromelia and melanoma (B-16) in (CBAxC57BL/6)F1 mice. |
| Databáze: | OpenAIRE |
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