A Prognostic Model To Predict Survival In Stage III Colon Cancer Patients Based on Histological Grade, Preoperative Carcinoembryonic Antigen Level and the Neutrophil Lymphocyte Ratio
| Autor: | Ke-Feng Wang, Yan-Da Lu, Haiyan Zhou, Xiaoqin Chen, Zhi-Jun Wuxiao, Xinbao Hao, Zhongjun Xia |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology Neutrophils Epidemiology Colorectal cancer Gastroenterology Young Adult Carcinoembryonic antigen Internal medicine Preoperative Care Biomarkers Tumor medicine Humans Lymphocytes Survival rate Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over biology business.industry Public Health Environmental and Occupational Health Middle Aged Prognosis medicine.disease Adenocarcinoma Mucinous Carcinoembryonic Antigen Survival Rate Oncology Relative risk Colonic Neoplasms Multivariate Analysis biology.protein Adenocarcinoma T-stage Female Lymph Nodes Lymph Neoplasm Grading business Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:747-751 |
| ISSN: | 1513-7368 |
| Popis: | Background: Stage III colon cancer patients demonstrate diverse clinical outcomes. The aim of this study was to develop a prognostic model in order to better predict their survival. Materials and Methods: From 2004 to 2010, 548 patients were retrospectively analyzed, among whom 328 were defined as the study group and the remaining 220 served as a validation group. Clinico-pathologic features, including age, gender, histological grade, T stage, number of positive lymph nodes, number of harvest lymph nodes, pretreatment carcinoembryonic antigen (CEA) levels and pretreatment neutrophil lymphocyte ratio (NLR), were collected. Kaplan-Meier survival curves were used to detect prognostic factors and multivariate analysis was applied to identify independent examples on which to develop a prognostic model. Finally, the model was further validated with the validation group. Results: Histological grade (p=0.002), T stage (p=0.011), number of positive lymph nodes (p=0.003), number of harvested lymph nodes (p=0.020), CEA (p=0.005), and NLR (p |
| Databáze: | OpenAIRE |
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