Hla-DPB1 mismatch in HLA-A-B-DRB1 identical sibling donor stem cell transplantation and acute graft-versus-host disease
| Autor: | Javier Zuazu, Marcos González, Antoni Torres, Enric Carreras, Salut Brunet, Rafael de la Cámara, José Alberto San Román, Jaime Pérez de Oteyza, Carlos Vallejo, Santiago Osorio, David Gallardo, Antonio M. Jimenez, Ildefonso Espigado, Jorge Sierra, M. Francisca González-Escribano, Manuela Alonso-Nieto, Juan R. González, Carmen Martiín, Guillermo Sanz, C Sanz-Rodriguez, David P. Serrano |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male HLA-DP Antigens Adolescent Graft vs Host Disease Human leukocyte antigen Histocompatibility Testing Biology Humans Cumulative incidence Sibling HLA-DP beta-Chains Aged Retrospective Studies Transplantation HLA-DPB1 HLA-A Antigens HLA-DR Antigens Middle Aged Tissue Donors HLA-A Histocompatibility surgical procedures operative HLA-B Antigens Immunology Acute Disease Female HLA-DRB1 Chains Stem Cell Transplantation |
| Zdroj: | Transplantation. 77(7) |
| ISSN: | 0041-1337 |
| Popis: | Background The role of human leukocyte antigen (HLA)-DPB1 as a transplantation antigen is controversial. A higher incidence of acute graft-versus-host disease (aGVHD) has been described after unrelated donor bone marrow transplant when both HLA-DPB1 alleles were mismatched. Methods We investigated the impact of a single HLA-DPB1 mismatch after HLA-A-B-DRB1 identical sibling donor transplantation on aGVHD. We analyzed 627 adult patient-donor pairs and identified 30 pairs without HLA-DPB1 identity (4.78%). In 17 cases, the patient had an allele that was not shared by the donor. Results The cumulative incidence of grades II-IV aGVHD was higher in the HLA-DPB1 mismatched group (66.7% vs. 35.7%, p=0.012). The HLA-DPB1 mismatch was identified by multivariate analysis as an independent risk factor for aGVHD (p=0.020, RR=2.68, 95% CI: 1.73-3.62). Conclusions HLA-DPB1 can mediate alloreactive responses. A single HLA-DPB1 mismatch increases the risk of aGVHD after sibling donor stem cell transplantation. |
| Databáze: | OpenAIRE |
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