Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan
| Autor: | Tenzinla Tenzinla, R.S. Morris, P.D. Jolly, Tandin Zangpo, Silas A. Davidson, Chencho Dorjee, Kezang Dorji, Joanna McKenzie, Sithar Dorjee, Yoenten Phuentshok, Ratree Takhampunya |
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| Rok vydání: | 2017 |
| Předmět: |
Bartonella
Orientia tsutsugamushi Time Factors Anaplasma Human granulocytic anaplasmosis 030231 tropical medicine Rodentia Disease Vectors Brief Communication 03 medical and health sciences 0302 clinical medicine Zoonoses medicine Animals Humans 030212 general & internal medicine Rickettsia Bhutan Phylogeny Disease Reservoirs Leptospira biology Bartonellosis Incidence rodent emerging infectious disease zoonosis biology.organism_classification medicine.disease bacterial infections and mycoses Virology Anaplasma phagocytophilum Bartonella grahamii Infectious Diseases Rickettsiosis Cross-Sectional Studies Emerging infectious disease surveillance Parasitology Leptospira interrogans Gram-Negative Bacterial Infections |
| Zdroj: | The Korean Journal of Parasitology |
| ISSN: | 1738-0006 |
| Popis: | Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a cross-sectional investigation of zoonotic disease pathogens in rodents was performed in Chukha district, Bhutan, where a high incidence of scrub typhus and cases of acute undifferentiated febrile illness had been reported in people during the preceding 4-6 months. Twelve rodents were trapped alive using wire-mesh traps. Following euthanasia, liver and kidney tissues were removed and tested using PCR for Orientia tsutsugamushi and other bacterial and rickettsial pathogens causing bartonellosis, borreliosis, human monocytic ehrlichiosis, human granulocytic anaplasmosis, leptospirosis, and rickettsiosis. A phylogenetic analysis was performed on all rodent species captured and pathogens detected. Four out of the 12 rodents (33.3%) tested positive by PCR for zoonotic pathogens. Anaplasma phagocytophilum, Bartonella grahamii, and B. queenslandensis were identified for the first time in Bhutan. Leptospira interrogans was also detected for the first time from rodents in Bhutan. The findings demonstrate the presence of these zoonotic pathogens in rodents in Bhutan, which may pose a risk of disease transmission to humans. |
| Databáze: | OpenAIRE |
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