Assessment of quality of life in clinical trials
| Autor: | Gabi Schulgen, Manfred Olschewski, Martin Schumacher |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Statistics and Probability
Clinical Trials as Topic medicine.medical_specialty Models Statistical Epidemiology Management science business.industry Alternative medicine humanities Survival Rate Clinical trial Quality of life (healthcare) Data Interpretation Statistical Activities of Daily Living Quality of Life medicine Humans Biostatistics Literature survey business |
| Zdroj: | Statistics in Medicine. 10:1915-1930 |
| ISSN: | 1097-0258 0277-6715 |
| DOI: | 10.1002/sim.4780101207 |
| Popis: | This paper is intended as an overview of developments in the assessment of quality of life (QOL) in clinical trials over the last decade from the viewpoint of clinical biostatistics. In the first part we deal with aspects of obtaining adequate measurements of quality of life. A literature survey shows that a large number of quite heterogeneous measurement approaches for use in clinical trials exist, a substantial percentage of which cannot be regarded as sufficient for their actual measuring purpose. In the second part we review statistical methods applied to and adapted for the analysis of QOL data. Underlying the analysis should be the assumption of QOL as a stochastic process. Applied analysis procedures are again investigated in a literature survey. Finally, critical conclusions are outlined and suggestions for further research are given. |
| Databáze: | OpenAIRE |
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