Passive cigarette smoke exposure induces airway hyperreactivity to histamine but not to acetylcholine in guinea-pigs
| Autor: | C. Omini, Gaetano Clavenna, G. Zuccari, A. Hernandez, Luisa Daffonchio |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Lung Diseases
Male Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Guinea Pigs Airway hyperresponsiveness In Vitro Techniques Pharmacology chemistry.chemical_compound In vivo medicine Animals Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Inflammation business.industry Cigarette smoke exposure Acetylcholine Airway hyperreactivity Passive Smoke Exposure chemistry Tobacco Smoke Pollution Bronchial Hyperreactivity business Airway Bronchoalveolar Lavage Fluid Histamine medicine.drug |
| Zdroj: | Pulmonary Pharmacology. 3:145-150 |
| ISSN: | 0952-0600 |
| Popis: | We have investigated the changes in airway reactivity induced in guinea-pigs by passive cigarette smoke exposure. In particular, we studied the development of airway hyperresponsiveness both in vivo and in vitro after passive exposure of the animals to cigarette smoke in a plexiglass box. Passive smoke exposure significantly (p less than 0.01) increased histamine induced bronchoconstriction. The dose-ratio calculated between histamine dose-response curves constructed in control and smoke exposed animals was 2.13 (95% confidence limits: 1.46-3.09). Acetylcholine induced bronchoconstriction was not potentiated after the same smoke exposure, indicating some specificity of the mediators involved in the airway hyperresponsiveness triggered by passive smoke exposure. The airway hyperreactivity induced by smoke exposure was associated with a specific increase in histamine contraction induced in vitro in lung parenchymal strips but not in tracheae or pulmonary arteries. Maximal histamine contraction in parenchymal strips taken from smoke exposed animals was significantly (p less than 0.01) enhanced by approximately 110% when compared to control. There was a significant (p less than 0.01) increase in the number of macrophages and eosinophils in the bronchoalveolar lavage fluid of animals passively exposed to cigarette smoke, but no mucus hypersecretion was evident. Our data demonstrate the occurrence of airway hyperreactivity induced by passive cigarette smoke exposure, which involves increased smooth muscle reactivity and cell recruitment. |
| Databáze: | OpenAIRE |
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