Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells
| Autor: | Christian Jorgensen, Rafael Contreras-Lopez, Claudia Terraza-Aguirre, Mauricio Campos-Mora, Farida Djouad, Roberto Elizondo-Vega, Patricia Luz-Crawford |
|---|---|
| Přispěvatelé: | Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Universidad de Concepción - University of Concepcion [Chile], Universidad de los Andes [Santiago] (UANDES), This work was supported by Inserm, the University of Montpellier, and Fondation Arthritis, Retiveau, Nolwenn |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
MESH: Cell Differentiation
Encephalomyelitis Autoimmune Experimental immunoregulation MESH: Th17 Cells [SDV.BC]Life Sciences [q-bio]/Cellular Biology Review Biology Mesenchymal Stem Cell Transplantation Immune system In vivo medicine Animals Humans MESH: Animals MESH: Mesenchymal Stem Cell Transplantation Secretion Th17 cells MESH: Encephalomyelitis Autoimmune Experimental [SDV.BC] Life Sciences [q-bio]/Cellular Biology lcsh:QH301-705.5 mesenchymal stem cells MESH: Humans Innate immune system Multiple sclerosis Mesenchymal stem cell Cell Differentiation General Medicine medicine.disease Phenotype In vitro Cell biology MESH: Mesenchymal Stem Cells lcsh:Biology (General) |
| Zdroj: | Cells, Vol 9, Iss 1660, p 1660 (2020) Cells Cells, 2020, 9 (7), pp.1660. ⟨10.3390/cells9071660⟩ |
| ISSN: | 2073-4409 |
| Popis: | International audience; Mesenchymal stem cells (MSCs) exhibit potent immunoregulatory abilities by interacting with cells of the adaptive and innate immune system. In vitro, MSCs inhibit the differentiation of T cells into T helper 17 (Th17) cells and repress their proliferation. In vivo, the administration of MSCs to treat various experimental inflammatory and autoimmune diseases, such as rheumatoid arthritis, type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, and bowel disease showed promising therapeutic results. These therapeutic properties mediated by MSCs are associated with an attenuated immune response characterized by a reduced frequency of Th17 cells and the generation of regulatory T cells. In this manuscript, we review how MSC and Th17 cells interact, communicate, and exchange information through different ways such as cell-to-cell contact, secretion of soluble factors, and organelle transfer. Moreover, we discuss the consequences of this dynamic dialogue between MSC and Th17 well described by their phenotypic and functional plasticity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|