Chemo- and Regioselective Direct Functional Group Installation through Catalytic Hydroxy Group Selective Conjugate Addition of Amino Alcohols to α,β-Unsaturated Sulfonyl Compounds
| Autor: | Zhao Li, Ryo Yazaki, Takashi Ohshima |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Sulfonyl
chemistry.chemical_classification 010405 organic chemistry Organic Chemistry Diol Regioselectivity 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Functional group Click chemistry Organic chemistry Azide Physical and Theoretical Chemistry Conjugate |
| Zdroj: | Organic Letters. 18:3350-3353 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A chemoselective functional group installation through catalytic hydroxy group selective conjugate addition of amino alcohols to a variety of functionalized α,β-unsaturated sulfonyl derivatives was developed. Azide group installation for click chemistry and facile fluorescent labeling onto the less reactive hydroxy group demonstrated the synthetic utility of the present chemoselective catalysis. Moreover, chemo- and regioselective reaction of an unprotected amino diol was achieved for the first time. |
| Databáze: | OpenAIRE |
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