Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in spontaneously hypertensive rats: effect of renal denervation
Autor: | Tetsuo Tanaka, Takuya Nishikawa, Satoshi Sawada, Toru Kawada, Satoru Suehara, Masaru Sugimachi, Minako Uenohara, Hiromi Yamamoto |
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Rok vydání: | 2020 |
Předmět: |
Denervation
Male medicine.medical_specialty Physiology business.industry Sodium Antidiuretic Effect Sympathetic nerve activity Diuresis Kidney Rats Urodynamics Blood pressure Endocrinology Internal medicine Creatinine Rats Inbred SHR medicine Animals Sympathetic innervation Arterial Pressure Sympathectomy business Urine flow Urine output |
Zdroj: | The journal of physiological sciences : JPS. 71(1) |
ISSN: | 1880-6562 |
Popis: | Primary acute sympathetic activation (PASA) causes a subsequent arterial pressure (AP) elevation. In this case, an antidiuretic effect via the renal innervation and pressure diuresis can act antagonistically on the kidneys. We examined the effect of PASA on urine output in spontaneously hypertensive rats (SHR) 4–7 days after unilateral renal denervation (RDN) (n = 9). The slope of the plot of urine flow versus AP was positive (0.120 ± 0.031 μL min−1 kg−1 mmHg−1) on the intact side, but it was less than 1/3 of the slope observed previously in normotensive Wistar–Kyoto rats (WKY). RDN did not normalize the slope of urine flow versus AP (0.179 ± 0.025 μL min−1 kg−1 mmHg−1, P = 0.098 versus the intact side). The urine flow at the operating point of the AP tended to be greater on the denervated than the intact side (29.0 ± 1.8 vs. 25.3 ± 1.9 μL min−1 kg−1, P = 0.055). The percent increase (17.2 ± 7.2%) was not different from that observed previously in WKY. Although high-resting sympathetic nerve activity is prerequisite for maintaining hypertension in SHR, the effect of sympathetic innervation on the urine output function was not greater than that in WKY. |
Databáze: | OpenAIRE |
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