Immunohistochemical demonstration of neurone specific enolase in bone marrow infiltrated by neuroblastoma
Autor: | O Hartmann, F Martinez-Madrigal, J. M. Caillaud, C Carlu |
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Rok vydání: | 1991 |
Předmět: |
endocrine system
Pathology medicine.medical_specialty Enolase Neurone specific enolase Bone marrow disease Pathology and Forensic Medicine Metastasis Immunoenzyme Techniques Neuroblastoma Bone Marrow Neoplasms hemic and lymphatic diseases Biomarkers Tumor medicine Humans neoplasms Phosphopyruvate hydratase business.industry Immune Sera General Medicine medicine.disease medicine.anatomical_structure nervous system Phosphopyruvate Hydratase Immunohistochemistry Bone marrow business Research Article |
Zdroj: | Journal of Clinical Pathology. 44:309-312 |
ISSN: | 0021-9746 |
Popis: | One hundred and two bone marrow samples were analysed by histological and immunohistochemical methods for neurone specific enolase (NSE). The biopsies were performed to determine the extent of bone marrow disease in 84 neuroblastomas, nine embryonal rhabdomyosarcomas, five Ewing's sarcomas, two cases of Hodgkin's disease and two lymphoblastic lymphomas. Twenty seven (32%) of neuroblastoma bone marrows showed metastases by conventional histological techniques and 33 (39%) after immunohistochemical staining with NSE. Five embryonal rhabdomyosarcomas, five Ewing's sarcomas, and two lymphoblastic lymphomas showed bone marrow metastases. Only one of these cases was reactive for NSE. NSE represents a very sensitive immunomarker for the follow up of neuroblastoma and improves detection of bone marrow invasion by neuroblastoma. |
Databáze: | OpenAIRE |
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