Suppression of spontaneous development of uterine adenomyosis and mammary hyperplastic alveolar nodules by Chinese herbal medicines in mice
| Autor: | Namiki H, Kuwa K, Manabu Matsuda, Kyokuwa M, Kawashima S, Takao Mori, Shinobu Sakamoto, Hiroshi Nagasawa |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Ratón Mammary gland Endometriosis Mammary Neoplasms Animal Paeonia law.invention Eating Mice Mammary Glands Animal Estrus law Oral administration Internal medicine medicine Glycyrrhiza Animals Adenomyosis Estrous cycle Hyperplasia business.industry Body Weight General Medicine medicine.disease Prolactin Drug Combinations Endocrinology medicine.anatomical_structure Complementary and alternative medicine Uterine Neoplasms Female business Phytotherapy Adenomyoma Mammary disorder Drugs Chinese Herbal |
| Zdroj: | The American journal of Chinese medicine. 21(3-4) |
| ISSN: | 0192-415X |
| Popis: | The effects of traditional Chinese herbal remedies, Shakuyaku-kanzo-to (SKT) and Hachimi-jiou-gan (HJG), on the spontaneous development of uterine adenomyosis and mammary hyperplastic alveolar nodules (HAN) were examined in an experimental animal model using SHN strain of mice. Female mice were provided with the chow containing 1% of SKT of HJG during 25-150 days of age. At 150 days of age, SKT treatment showed significantly lower incidence of adenomyosis, and HJG treatment resulted in a significantly lower incidence of HAN when compared to a control chow containing no medicines. Long-term exposure to these herbal medicines affected little serum prolactin (PRL) level, estrous cycle, food intake and body growth. Thus, the present mouse data suggest that the oral administration of these herbal medicines is a useful tool for the treatment of uterine adenomyosis or mammary disorder such as cystic mastitis. |
| Databáze: | OpenAIRE |
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