Myocardial contractility impairment with racemic bupivacaine, non-racemic bupivacaine and ropivacaine. A comparative study
| Autor: | Leopoldo Muniz da Silva, Adriana Hepner, Dijon Henrique Salomé de Campos, Eliana Marisa Ganem, Antonio Carlos Cicogna, Matheus Fécchio Pinotti |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Time Factors RD1-811 medicine.drug_class Isometric exercise Contractility Racemic bupivacaine Reference Values medicine Animals Ropivacaine Anesthetics Local Rats Wistar Anesthetics Bupivacaine Cardiotoxicity Chemistry Local anesthetic Stereoisomerism Papillary Muscles Amides Myocardial Contraction Rats Local Anesthesia Depression Chemical Muscle Tonus Time to peak Surgery medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Vol 30, Iss 7, Pp 484-490 (2015) PubMed Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Acta Cirurgica Brasileira, Volume: 30, Issue: 7, Pages: 484-490, Published: JUL 2015 Acta Cirúrgica Brasileira v.30 n.7 2015 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 0102-8650 |
| Popis: | Made available in DSpace on 2015-12-07T15:31:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2015. Added 1 bitstream(s) on 2015-12-07T15:54:08Z : No. of bitstreams: 1 S0102-86502015000700484.pdf: 443014 bytes, checksum: 819306b4d423c3f330eb6c85771bb2ac (MD5) To study racemic bupivacaine, non-racemic bupivacaine and ropivacaine on myocardial contractility. Isolated Wistar papillary muscles were submitted to 50 and 100 mM racemic bupivacaine (B50 and B100), non-racemic bupivacaine (NR50 and NR100) and ropivacaine (R50 and R100) intoxication. Isometric contraction data were obtained in basal condition (0.2 Hz), after increasing the frequency of stimulation to 1.0 Hz and after 5, 10 and 15 min of local anesthetic intoxication. Data were analyzed as relative changes of variation. Developed tension was higher with R100 than B100 at D1 (4.3 ± 41.1 vs -57.9 ± 48.1). Resting tension was altered with B50 (-10.6 ± 23.8 vs -4.7 ± 5.0) and R50 (-14.0 ± 20.5 vs -0.5 ± 7.1) between D1 and D3. Maximum rate of tension development was lower with B100 (-56.6 ± 38.0) than R50 (-6.3 ± 37.9) and R100 (-1.9 ± 37.2) in D1. B50, B100 and NR100 modified the maximum rate of tension decline from D1 through D2. Time to peak tension was changed with NR50 between D1 and D2. Racemic bupivacaine depressed myocardial contractile force more than non-racemic bupivacaine and ropivacaine. Non-racemic and racemic bupivacaine caused myocardial relaxation impairment more than ropivacaine. Universidade Estadual Paulista, Departamento de Anestesiologia, Faculdade de Medicina de Botucatu Universidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu |
| Databáze: | OpenAIRE |
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