Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial
| Autor: | Nancy W. Glynn, Patricia M. Kearney, Nicolas Rodondi, Simon P. Mooijaart, Manuel R. Blum, Mirah J Stuber, Tinh-Hai Collet, Vera J. C. McCarthy, Elisavet Moutzouri, Drahomir Aujesky, David J. Stott, Martin Feller, Rudi G. J. Westendorp, Jacobijn Gussekloo, Cinzia Del Giovane, Douglas C. Bauer |
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| Přispěvatelé: | Newman, Anne |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics Aging medicine.medical_treatment Psychological intervention Placebo-controlled study THE JOURNAL OF GERONTOLOGY: Medical Sciences Levothyroxine Thyrotropin 030204 cardiovascular system & hematology AcademicSubjects/MED00280 0302 clinical medicine 80 and over 030212 general & internal medicine Fatigue Thyroid disease Subclinical infection Aged 80 and over ddc:616 Thyroid 3. Good health medicine.anatomical_structure Mental Health 6.1 Pharmaceuticals Female medicine.drug medicine.medical_specialty Clinical Trials and Supportive Activities Clinical Sciences Virtual Collection: Fatigue Sedentary and Accelerometry Part 2 610 Medicine & health Placebo 03 medical and health sciences Hypothyroidism Clinical Research 360 Social problems & social services medicine Humans Aged business.industry Evaluation of treatments and therapeutic interventions medicine.disease Thyroxine Asymptomatic Diseases AcademicSubjects/SCI00960 Hormone therapy Geriatrics and Gerontology business Gerontology |
| Zdroj: | Stuber, Mirah J.; Moutzouri, Elisavet; Feller, Martin; Del Giovane, Cinzia; Bauer, Douglas C; Blum, Manuel R.; Collet, Tinh-Hai; Gussekloo, Jacobijn; Mooijaart, Simon P; McCarthy, Vera J C; Aujesky, Drahomir; Westendorp, Rudi; Stott, David J; Glynn, Nancy W; Kearney, Patricia M; Rodondi, Nicolas (2020). Effect of Thyroid Hormone Therapy on Fatigability in Older Adults With Subclinical Hypothyroidism: A Nested Study Within a Randomized Placebo-Controlled Trial. Journals of gerontology. Series A-biological sciences and medical sciences, 75(9), e89-e94. Oxford University Press 10.1093/gerona/glaa123 The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Stuber, M J, Moutzouri, E, Feller, M, Del Giovane, C, Bauer, D C, Blum, M R, Collet, T H, Gussekloo, J, Mooijaart, S P, McCarthy, V J C, Aujesky, D, Westendorp, R, Stott, D J, Glynn, N W, Kearney, P M, Rodondi, N & Newman, A 2020, ' Effect of Thyroid Hormone Therapy on Fatigability in Older Adults with Subclinical Hypothyroidism : A Nested Study within a Randomized Placebo-Controlled Trial ', Journals of Gerontology-Series A Biological Sciences and Medical Sciences, vol. 75, no. 9, pp. e89-e94 . https://doi.org/10.1093/gerona/glaa123 The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 75(9), E89-E94. OXFORD UNIV PRESS INC The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 75, No 9 (2020) pp. e89-e94 The journals of gerontology. Series A, Biological sciences and medical sciences, vol 75, iss 9 |
| ISSN: | 1079-5006 |
| DOI: | 10.1093/gerona/glaa123 |
| Popis: | Author(s): Stuber, Mirah J; Moutzouri, Elisavet; Feller, Martin; Del Giovane, Cinzia; Bauer, Douglas C; Blum, Manuel R; Collet, Tinh-Hai; Gussekloo, Jacobijn; Mooijaart, Simon P; McCarthy, Vera JC; Aujesky, Drahomir; Westendorp, Rudi; Stott, David J; Glynn, Nancy W; Kearney, Patricia M; Rodondi, Nicolas | Abstract: BackgroundFatigue often triggers screening for and treatment of subclinical hypothyroidism. However, data on the impact of levothyroxine on fatigue is limited and previous studies might not have captured all aspects of fatigue.MethodThis study is nested within the randomized, placebo-controlled, multicenter TRUST trial, including community-dwelling participants aged ≥65 and older, with persistent subclinical hypothyroidism (TSH 4.60-19.99 mIU/L, normal free thyroxine levels) from Switzerland and Ireland. Interventions consisted of daily levothyroxine starting with 50 μg (25 μg if weight l50 kg or known coronary heart diseases) together with dose adjustments to achieve a normal TSH and mock titration in the placebo group. Main outcome was the change in physical and mental fatigability using the Pittsburgh Fatigability Scale over 1 year, assessed through multivariable linear regression with adjustment for country, sex, and levothyroxine starting dose.ResultsAmong 230 participants, the mean ± standard deviation (SD) TSH was 6.2 ± 1.9 mIU/L at baseline and decreased to 3.1 ± 1.3 with LT4 (n = 119) versus 5.3 ± 2.3 with placebo (n = 111, p l .001) after 1 year. After adjustment we found no between-group difference at 1 year on perceived physical (0.2; 95% CI -1.8 to 2.1; p = .88), or mental fatigability (-1.0; 95% CI -2.8 to 0.8; p = .26). In participants with higher fatigability at baseline (≥15 points for the physical score [n = 88] or ≥13 points for the mental score [n = 41]), the adjusted between-group differences at 1 year were 0.4 (95% CI -3.6 to 2.8, p = .79) and -2.2 (95% CI -8.8 to 4.5, p = .51).ConclusionsLevothyroxine in older adults with mild subclinical hypothyroidism provides no change in physical or mental fatigability. |
| Databáze: | OpenAIRE |
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