Modified technique of submandibular gland transfer followed by intensity modulated radiotherapy to reduce xerostomia in head and neck cancer patients
| Autor: | Matt S Susko, Chase M. Heaton, Sue S. Yom, Chia-Fan Chang, Patrick K. Ha, Ivan H Ei-Sayed, William R. Ryan, Jonathan R. George |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Submandibular Gland Facial artery Xerostomia 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine stomatognathic system medicine.artery medicine Humans Parotid Gland Vein Adverse effect business.industry Head and neck cancer medicine.disease Submandibular gland Radiation therapy stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Head and Neck Neoplasms Pilocarpine 030220 oncology & carcinogenesis Radiotherapy Intensity-Modulated Intensity modulated radiotherapy Radiology Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | Head & Neck. 42:2340-2347 |
| ISSN: | 1097-0347 1043-3074 |
| DOI: | 10.1002/hed.26249 |
| Popis: | Background Xerostomia is one of the most common long-term adverse effects of radiotherapy for head and neck cancer patients. Contralateral submandibular gland transfer (SMG-T) before radiotherapy was shown to reduce xerostomia compared to pilocarpine. We sought to evaluate a modification of this surgery preserving the ipsilateral facial artery and vein to simplify the SMG-T. Methods Eighteen patients planned for head and neck intensity modulated radiotherapy to both necks were reviewed. Surgical complications were recorded. The grade of xerostomia was assessed after treatment completion. Results There were no minor or major complications resulting from the modified SMG-T. At 24.5-months follow up, the incidence of post-treatment moderate to severe xerostomia was 16.7%. No locoregional recurrence occurred. Only one patient had distant solitary lung metastasis. Conclusion The modified SMG-T technique is a practical and effective method to reduce the dose of radiation to the contralateral SMG and limit post-treatment xerostomia. |
| Databáze: | OpenAIRE |
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