The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies
| Autor: | Beekhuijzen, Manon, Schneider, Steffen, Barraclough, Narinder, Hallmark, Nina, Hoberman, Alan, Lordi, Sheri, Moxon, Mary, Perks, Deborah, Piersma, Aldert H, Makris, Susan L, Sub RIVM, dIRAS RA-1 |
|---|---|
| Přispěvatelé: | Sub RIVM, dIRAS RA-1 |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Thyroid Hormones medicine.medical_specialty Thyroid Gland/drug effects Toxicity Tests/methods Standardization Reproductive toxicology Thyroid Gland Guidelines as Topic/standards Guidelines as Topic Harmonization Endocrine Disruptors Thyroid Function Tests Toxicology Thyroid function tests Endocrine Disruptors/toxicity 03 medical and health sciences Toxicity Tests medicine Animals Intensive care medicine Reproduction/drug effects Clinical Laboratory Techniques/methods medicine.diagnostic_test Clinical Laboratory Techniques business.industry Reproduction Interpretation (philosophy) Thyroid Reference Standards Thyroid Hormones/blood 030104 developmental biology medicine.anatomical_structure Female Risk assessment business Hormone |
| Zdroj: | Reproductigve Toxicoloy, 80, 126. Elsevier |
| ISSN: | 0890-6238 |
| Popis: | In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the collection, assessment, and interpretation of thyroid hormone data for regulatory toxicology and risk assessment. Clarification and guidance is needed for 1) timing and methods of blood collection, 2) standardization and validation of the analytical methods, 3) triggers for additional measurements, 4) the need for T4 measurements in postnatal day (PND) 4 pups, and 5) the interpretation of changes in thyroid hormone levels regarding adversity. Discussions on these topics have already been initiated, and involve expert scientists from a number of international multisector organizations. This paper provides an overview of existing issues, current activities and recommendations for moving forward. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect