Lymphocyte hyporesponsiveness during edema, proteinuria and hypertension (EPH) gestosis
| Autor: | Pietro Zucchelli, Marcora Mandreoli, Leonardo Cagnoli, Sonia Pasquali, Raffaele Parente, Elisabetta Beltrandi, Mauro Sasdelli |
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| Rok vydání: | 1981 |
| Předmět: |
Adult
medicine.medical_specialty Rosette Formation Lymphocyte Clinical Biochemistry Lymphocyte Activation Group A Group B Pathogenesis Pre-Eclampsia Pregnancy Internal medicine Edema medicine Humans Eclampsia Phytohemagglutinins Immunity Cellular Hematology Proteinuria business.industry medicine.disease Endocrinology medicine.anatomical_structure Immunology Female medicine.symptom business |
| Zdroj: | La Ricerca in clinica e in laboratorio. 11(3) |
| ISSN: | 0390-5748 |
| Popis: | In vitro immunological tests showed that patients with pre-eclampsia are characterized by a greater degree of lymphocyte hyporesponsiveness to mitogens during pregnancy than normotensive controls. Thus, a relationship has been hypothesized between the hypoimmune lymphocyte response and the pathogenesis of the disease. We studied 20 non-pregnant healthy volunteers (group a), 11 women with a normal pregnancy (group b) and 13 women with EPH gestosis (group c). In all patients we determined the number of lymphocytes and the lymphocyte function (PHA, Con A, PWM responsiveness) in autologous and homologous plasma during pregnancy and 5 to 30 days after delivery. The mean values of the number of EAC and E rosettes in the three groups studied were similar. The mean values of the mitogenic response to PHA in autologous plasma were significantly reduced in both groups b and c in comparison with group a, but there was no statistical difference between groups b and c. The PHA lymphocyte responsiveness returned to normal in both homologous and autologous plasma after delivery. Our data demonstrate that no difference exists between pregnant women with and without pre-eclampsia as regards impaired cell-mediated lymphocyte response in vitro. Moreover, the diminished lymphocyte responsiveness to mitogens during pregnancy seems to be due to humoral circulating factor(s). |
| Databáze: | OpenAIRE |
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