ASSOCIATION OF SCHISTOSOMA HAEMATOBIUM INFECTION WITH PROTECTION AGAINST ACUTE PLASMODIUM FALCIPARUM MALARIA IN MALIAN CHILDREN
| Autor: | Karim Traore, Kirsten E. Lyke, Alassane Dicko, Abdoulaye K. Kone, Ogobara K. Doumbo, Marcelo B. Sztein, Abdoulaye Dabo, Drissa Coulibaly, Lansana Sangaré, Issa Diarra, Christopher V. Plowe, Modibo Daou, Ando B. Guindo |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Adolescent Endemic Diseases Plasmodium falciparum Population Helminthiasis Schistosomiasis Parasitemia Mali Asymptomatic Article Feces Schistosomiasis haematobia Age Distribution Risk Factors Virology parasitic diseases medicine Animals Humans Longitudinal Studies Prospective Studies Malaria Falciparum Child education Schistosoma haematobium education.field_of_study biology Age Factors medicine.disease biology.organism_classification Infectious Diseases Case-Control Studies Child Preschool Acute Disease Immunology Female Parasitology medicine.symptom Malaria |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 73:1124-1130 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.2005.73.1124 |
| Popis: | Plasmodium falciparum and Schistosoma haematobium are co-endemic parasitic diseases with worldwide distribution. Evidence suggests interactions occur between helminthic and malaria infections, although it is unclear whether this effect is beneficial or harmful to the host. Malian children 4-14 years of age with asymptomatic S. haematobium infection (SP) (n = 338) were prospectively matched by age, sex, and residence to children without schistosomiasis (SN) (n = 338) who were cleared of occult intestinal parasites, and followed-up for one malaria transmission season (25 weeks). The time to the first clinical malaria infection, incidence of malaria episodes, and parasitemia were recorded. Age associated protection from malaria in children with schistosomiasis was observed. SP children (4-8 years of age) compared with SN children demonstrated delayed time to first clinical malaria infection (74 versus 59 days; P = 0.04), fewer numbers of malaria episodes (1.55 versus 1.81 infections; P = 0.03) and lower geometric mean parasite densities (6,359 versus 9,874 asexual forms/mm(3); P = 0.07) at first infection. No association between schistosomiasis and P. falciparum malaria was observed in children 9-14 years of age. We conclude that underlying schistosomiasis is associated with protection against clinical falciparum malaria in an age-dependent manner. |
| Databáze: | OpenAIRE |
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