Methylprednisolone as a memory enhancer in rats: Effects on aversive memory, long-term potentiation and calcium influx
| Autor: | Angela Regina Piovesan, Wilson Alves-Do-Prado, Marcus Vinicius Soares de Lara, Michelle Flores Domingues, Pâmela Billig Mello-Carpes, A.P. Corrado, Lucia Vinade, Zaquer Suzana Munhoz Costa-Ferro, Denis de Assis, Rithiele Gonçalves, Cháriston André Dal Belo, Ivan Izquierdo, Paulo Correia-de-Sá, Simone Denise Salamoni, Jaderson Costa da Costa, Liane da Silva de Vargas |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Long-Term Potentiation Hippocampal formation Inhibitory postsynaptic potential Hippocampus Methylprednisolone 03 medical and health sciences 0302 clinical medicine Memory Internal medicine medicine Animals Rats Wistar Enhancer CA1 Region Hippocampal Molecular Biology General Neuroscience Long-term potentiation Rats 030104 developmental biology Endocrinology Synapses Calcium Neurology (clinical) Psychology Calcium influx Neuroscience 030217 neurology & neurosurgery Intracellular Developmental Biology Hormone medicine.drug |
| Zdroj: | Brain Research. 1670:44-51 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2017.06.007 |
| Popis: | It is well recognized that stress or glucocorticoids hormones treatment can modulate memory performance in both directions, either impairing or enhancing it. Despite the high number of studies aiming at explaining the effects of glucocorticoids on memory, this has not yet been completely elucidated. Here, we demonstrate that a low daily dose of methylprednisolone (MP, 5 mg/kg, i.p.) administered for 10-days favors aversive memory persistence in adult rats, without any effect on the exploring behavior, locomotor activity, anxiety levels and pain perception. Enhanced performance on the inhibitory avoidance task was correlated with long-term potentiation (LTP), a phenomenon that was strengthen in hippocampal slices of rats injected with MP (5 mg/kg) during 10 days. Additionally, in vitro incubation with MP (30–300 µM) concentration-dependently increased intracellular [Ca2+]i in cultured hippocampal neurons depolarized by KCl (35 mM). In conclusion, a low daily dose of MP for 10 days may promote aversive memory persistence in rats. |
| Databáze: | OpenAIRE |
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