Clinical spectrum of non-alcoholic fatty liver disease in diabetic and non-diabetic patients

Autor: George Boon-Bee Goh, Ruth Sargent, Srinivasan Dasarathy, Jaividhya Dasarathy, Aynur Unalp-Arida, Achuthan Sourianarayanane, Rish K. Pai, Arthur J. McCullough, Mangesh R. Pagadala, Carol Hawkins, Amer Khiyami, Lisa Yerian
Rok vydání: 2015
Předmět:
Very low-density lipoprotein
BMI
body mass index
LDL
low density lipoprotein cholesterol
INR
international normalised ratio
AST
aspartate aminotransferase
Disease
Gastroenterology
Fibrosis score
NFS
NAFLD fibrosis score
DM
type 2 diabetes mellitus
apoB-100
apolipoprotein B-100
NAS
NAFLD activity score
TGs
triglycerides
Fatty liver
Regular Article
Non-diabetic
ACE-I
angiotensin-converting enzyme-inhibitor
3. Good health
ARB
angiotensin receptor blocker
Molecular Medicine
Non diabetic
NAFLD
non-alcoholic fatty liver disease
medicine.medical_specialty
NASH
non-alcoholic steatohepatitis
NASH CRN
Non-alcoholic Steatohepatitis Clinical Research Network
ORs
odd ratios
digestive system
VLDL
very-low-density lipoproteins
Pathology and Forensic Medicine
ER
endoplasmic reticulum
Diabetic
ALT
alanine aminotransferase
NAFLD
Physiology (medical)
Diabetes mellitus
Internal medicine
medicine
FFAs
free-fatty acids
In patient
Chol
total cholesterol
ALP
alkaline phosphatase
business.industry
SDs
standard deviations
nutritional and metabolic diseases
Non alcoholic
NAFLD fibrosis score
medicine.disease
CIs
confidence intervals
digestive system diseases
HDL
high density lipoprotein cholesterol
Endocrinology
HOMA-IR
Homeostatic model assessment—insulin resistance
business
Zdroj: BBA Clinical
ISSN: 2214-6474
DOI: 10.1016/j.bbacli.2014.09.001
Popis: Background While non-alcoholic fatty liver disease (NAFLD) has been well characterised in patients with diabetes mellitus (DM), less is known about NAFLD in non-DM patients. We investigated the clinical characteristics of NAFLD patients with and without DM and accuracy of the NAFLD fibrosis score (NFS) in these two NAFLD groups. Methods Clinical, biochemical and histological variables were evaluated in this prospective cross-sectional study of 503 patients with biopsy proven NAFLD. Comparisons between patients with and without DM were analysed. NFS was correlated with liver histology to assess its robustness in patients with and without DM. Results There were 503 biopsy proven NAFLD patients with 48% of the cohort being diabetic. Relative to patients without DM, patients with DM were older (52 vs. 46 years, p
Highlights • Patients with diabetes have more severe NAFLD based on histology. • Severe NAFLD can occur in a considerable proportion of non-diabetic NAFLD patients. • The NAFLD fibrosis score may be less accurate in non-diabetics.
Databáze: OpenAIRE
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