Parallel computation enables precise description of Ca2+ distribution in nerve terminals
| Autor: | S. Aharon, M. Bercovier, H. Parnas |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pharmacology
Nerve Endings Neurotransmitter Agents General Mathematics General Neuroscience Immunology Models Neurological General Biochemistry Genetics and Molecular Biology Membrane Potentials Computational Theory and Mathematics Animals Calcium General Agricultural and Biological Sciences Mathematics General Environmental Science |
| Zdroj: | Bulletin of mathematical biology. 58(6) |
| ISSN: | 0092-8240 |
| Popis: | Parallel computation employing a domain decomposition method was used to calculate precisely without approximations the spatio-temporal distribution of Ca2+ in nerve terminals. The results showed, contrary to expectations, that for equal admitted Ca2+ currents at low (one channel open) and high (four channels open) depolarization, the average Ca2+ concentration at the release area is higher at the low depolarization. These calculations provide additional support for the Ca(2+)-voltage hypothesis for neurotransmitter release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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