Enhancement of gold-nanocluster-mediated chemotherapeutic efficiency of cisplatin in lung cancer
| Autor: | Mengting Chen, Yuchen Lin, Xiaocui Fang, Yanlian Yang, Chen Wang, Mingpeng Liu, Lilusi Ma, Jingyi Liu, Mei Jiang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lung Neoplasms
Biomedical Engineering Deep penetration Metal Nanoparticles Antineoplastic Agents Peptide 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Nanoclusters In vivo Cell Line Tumor polycyclic compounds medicine Humans General Materials Science Lung cancer Cisplatin chemistry.chemical_classification Chemistry Drug Synergism General Chemistry General Medicine 021001 nanoscience & nanotechnology medicine.disease Xenograft Model Antitumor Assays 0104 chemical sciences Drug Resistance Neoplasm Cancer research Gold Delivery system 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Materials Chemistry B. 9:4895-4905 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/d1tb00276g |
| Popis: | A novel delivery system for cisplatin was constructed based on electrostatics-mediated assemblies of gold nanoclusters and PEGylated cationic peptide (cisplatin@GC-pKs). Encapsulated cisplatin in the as-formed micelle like assemblies was observed to demonstrate improved cellar uptake and enhanced chemotherapeutic efficiency in the cisplatin-resistant lung cancer cells. In vivo assays further confirmed that cisplatin@GC-pKs had profound anti-tumor efficiency due to deep penetration and accumulation of nanoscale cisplatin@GC-pKs via the enhanced permeability and retention (EPR) effect at tumor tissues. The constructed cisplatin@GC-pKs in this work demonstrated enhanced anti-tumor activity for lung cancer therapy, as well as a potential treatment strategy for a variety of cisplatin-resistance related malignancies. |
| Databáze: | OpenAIRE |
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