Patterns of cytomegalovirus retinitis at a tertiary referral center in Turkey
| Autor: | Ilknur Tugal-Tutkun, Zafer Cebeci, Muhammed Talha Sadik, Merih Oray, Nur Kir, Nihan Aksu Ceylan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures Turkey Immune recovery uveitis Human immunodeficiency virus (HIV) Retinitis HIV Infections medicine.disease_cause Antiviral Agents Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Vitreous haze business.industry virus diseases Odds ratio medicine.disease eye diseases Ophthalmology Cytomegalovirus Retinitis 030221 ophthalmology & optometry Referral center Cytomegalovirus retinitis medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | International ophthalmology. 41(9) |
| ISSN: | 1573-2630 |
| Popis: | To analyze predisposing conditions in Turkish patients with CMV retinitis and to compare HIV-positive and HIV-negative patients. We reviewed medical charts and ocular images of 41 patients with CMV retinitis diagnosed between 1996 and 2019. Eleven patients (27%) had HIV infection and 30 were immunocompromised from diverse causes. Initial visual acuity, type, zone, and extent of CMV retinitis, and response to anti-CMV treatment were not significantly different between the two groups. Vitreous haze and panretinal occlusive vasculopathy were the presenting features only in non-HIV patients, seen in 34% and 16% of eyes, respectively. Although not statistically significant, recurrent CMV retinitis was more common in non-HIV patients (17.4% vs. 4.3%/eye-year) and immune recovery uveitis was more common in HIV patients (43% vs. 26%/eye-year). Visual outcomes were similar. Final visual acuity of 1 logMAR or worse was significantly associated with the recurrence of CMV retinitis (odds ratio 9.67; p = 0.01) and also with the occurrence of immune recovery uveitis (odds ratio 4.31; p = 0.058). Diverse immunocompromising conditions are more commonly associated with CMV retinitis than HIV infection in Turkish patients. Intraocular inflammation was more commonly associated with active retinitis in non-HIV patients and immune recovery uveitis was more common in HIV patients. |
| Databáze: | OpenAIRE |
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