IL-6 and IL-1 receptor antagonist in stable angina pectoris and relation of IL-6 to clinical findings in acute myocardial infarction
| Autor: | B. Wretlind, Staffan Ahnve, Amon S. Gabriel, Arne Martinsson |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Fever medicine.drug_class Sialoglycoproteins Myocardial Infarction Inflammation Angina Pectoris Coronary artery disease Internal medicine Internal Medicine medicine Humans Myocardial infarction Interleukin 6 Aged Heart Failure biology Interleukin-6 business.industry Antagonist Receptors Interleukin-1 Middle Aged medicine.disease Receptor antagonist Interleukin 1 Receptor Antagonist Protein Heart failure biology.protein Coronary care unit Cardiology Female medicine.symptom business |
| Zdroj: | Journal of Internal Medicine. 248:61-66 |
| ISSN: | 1365-2796 0954-6820 |
| Popis: | Gabriel AS, Ahnve S, Wretlind B, Martinsson A (Karolinska Institute and Huddinge University Hospital, Stockholm, Sweden). J Intern Med 2000; 248: 61–66. Objectives. To determine if increased inflammatory activity, as reflected by interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1ra) levels, is present in patients with stable angina pectoris and if IL-6 levels on admission to the coronary care unit in patients with acute myocardial infarction (AMI) are related to heart failure and fever response. Subjects and methods. We studied 28 patients with stable angina pectoris enrolled for coronary angiography, and compared them with sex- and age-matched controls. Thirty-four patients with AMI were studied and samples for determination of IL-6 levels were taken on admission within 36 h of onset of symptoms. IL-6 and IL-1ra were determined in serum by enzyme immunoassay. Results. Levels of IL-6 and IL-1ra were higher in patients with stable angina pectoris than in controls (mean 4.6 ± 3.6 vs. 3.0 ± 2.9 ng L–1, P 4 days) had higher IL-6 levels (94.7 ± 138.2 vs. 21.7 ± 29.7 ng L–1, P |
| Databáze: | OpenAIRE |
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