Association of a Novel Diagnostic Biomarker, the Plasma Cardiac Bridging Integrator 1 Score, With Heart Failure With Preserved Ejection Fraction and Cardiovascular Hospitalization
| Autor: | Jon A. Kobashigawa, Alan H. B. Wu, Jignesh Patel, Babak Azarbal, TingTing Hong, Andriana P. Nikolova, Antoine Hage, Jaime Moriguchi, David Chang, Yu Xie, Rachel Baum, Michele A. Hamilton, Lawrence S.C. Czer, Ana-Maria Caldaruse, Sosse Agvanian, Tara C. Hitzeman, Robin M. Shaw, Dael Geft, Michelle M. Kittleson |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty 030204 cardiovascular system & hematology Severity of Illness Index Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine Severity of illness Natriuretic Peptide Brain Medicine Humans Protein Precursors Adaptor Proteins Signal Transducing Heart Failure Ejection fraction business.industry Tumor Suppressor Proteins Hazard ratio Nuclear Proteins Stroke Volume Middle Aged medicine.disease Prognosis Peptide Fragments Hospitalization 030104 developmental biology Heart failure Cardiology Female Cardiology and Cardiovascular Medicine business Heart failure with preserved ejection fraction Body mass index Biomarkers Cohort study Follow-Up Studies |
| Zdroj: | JAMA cardiology. 3(12) |
| ISSN: | 2380-6591 |
| Popis: | Importance Transverse tubule remodeling is a hallmark of heart failure. Cardiac bridging integrator 1 (cBIN1) is a circulating membrane scaffolding protein that is essential for transverse tubule health, and its plasma level declines with disease. Objective To determine if a cBIN1-derived score can serve as a diagnostic biomarker of heart failure with preserved ejection fraction (HFpEF). Design, Setting, and Participants In this cohort study, the cBIN1 score (CS) was determined from enzyme-linked immunoabsorbent assay-measured plasma cBIN1 concentrations from study participants in an ambulatory heart failure clinic at Cedars-Sinai Medical Center. Consecutive patients with a confirmed diagnosis of heart failure with preserved ejection fraction (HFpEF; defined by a left ventricular ejection fraction ≥50%) were recruited from July 2014 to November 2015 and compared with age-matched and sex-matched healthy volunteers with no known cardiovascular diagnoses and participants with risk factors for heart failure but no known HFpEF. Baseline characteristics and 1-year longitudinal clinical information were obtained through electronic medical records. Data analysis occurred from November 2016 to November 2017. Main Outcomes and Measures The analysis examined the ability of the CS and N-terminal pro-B-type natriuretic peptide (NT-proBNP) results to differentiate among patients with HFpEF, healthy control participants, and control participants with risk factors for heart failure. We further explored the association of the CS with future cardiovascular hospitalizations. Results A total of 52 consecutive patients with a confirmed diagnosis of HFpEF were enrolled (mean [SD] age, 57 [15] years; 33 [63%] male). The CS values are significantly higher in the patients with HFpEF (median [interquartile range (IQR)], 1.85 [1.51-2.28]) than in the 2 control cohorts (healthy control participants: median [IQR], -0.03 [-0.48 to 0.41]; control participants with risk factors only: median [IQR], -0.08 [-0.75 to 0.42]; P |
| Databáze: | OpenAIRE |
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