Exaggeration of the cholecystokinin-induced motor response in the cat gastrointestinal tract
| Autor: | Sylvia Wiese, Stuart V. Pineo, Richard A. Gillis, Robert J. Gould, David Jevsevar, Allen W. Mangel, Kenton M. Sanders |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Colon Stimulation Bethanechol Colonic Diseases Functional Biology digestive system Jejunum Bethanechol Compounds Digestive System Physiological Phenomena Internal medicine medicine Animals Infusions Intravenous Pylorus Cholecystokinin digestive oral and skin physiology Gastroenterology Gallbladder Smooth muscle contraction digestive system diseases medicine.anatomical_structure Endocrinology Gastrointestinal hormone Duodenum Cats Digestive System hormones hormone substitutes and hormone antagonists medicine.drug Muscle Contraction |
| Zdroj: | Digestion. 43(4) |
| ISSN: | 0012-2823 |
| Popis: | A stimulation of distal colonic motor activity was produced in anesthetized cats following intravenous administration of cholecystokinin. The contractile response elicited by cholecystokinin was not reduced following pretreatment with atropine. However, when animals were treated with agents which increased the net cholinergic input to the colon, a marked exaggeration of the subsequent cholecystokinin-induced response occurred. This cholinergically mediated exaggeration was produced following administration of the cholinergic agonist bethanechol, or after removal of tonic inhibitory systems mediated by prostaglandin or alpha-adrenergic input, whose blockade results in atropine-sensitive colonic stimulation. Cholecystokinin was also found to produce stimulation of motor activity in the pylorus, jejunum, proximal colon and gallbladder. Cholinergically mediated exaggeration of the cholecystokinin response was also present in the pylorus and proximal colon, but not gallbladder or jejunum. An inhibition of spontaneous motor activity was produced in the ileum or duodenum following cholecystokinin administration. |
| Databáze: | OpenAIRE |
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